Low effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 mid–season results

Richard Pebody; F. Warburton; Joanna Ellis; Nicholas Andrews; Catherine Thompson; B. Von Wissmann; Helen Green; S. Cottrell; J. Johnston; S. De Lusignan; C. Moore; R. Gunson; C. Robertson; J. McMenamin; Maria Zambon

doi:10.2807/1560-7917.ES2015.20.5.21025

Low effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 mid–season results

Richard Pebody^*
, F. Warburton
, Joanna Ellis
, Nicholas Andrews
, Catherine Thompson
, B. Von Wissmann
, Helen Green
, S. Cottrell
, J. Johnston
, S. De Lusignan
, C. Moore
, R. Gunson
, C. Robertson
, J. McMenamin
, Maria Zambon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

95 Citations (Scopus)

Abstract

In 2014/15 the United Kingdom experienced circulation of influenza A(H3N2) with impact in the elderly. Midseason vaccine effectiveness (VE) shows an adjusted VE of 3.4% (95% CI: −44.8 to 35.5) against primary care consultation with laboratory-confirmed influenza and −2.3% (95% CI: −56.2 to 33.0) for A(H3N2). The low VE reflects mismatch between circulating viruses and the 2014/15 northern hemisphere A(H3N2) vaccine strain. Early use of antivirals for prophylaxis and treatment of vulnerable populations remains important.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Eurosurveillance
Volume	20
Issue number	5
DOIs	https://doi.org/10.2807/1560-7917.ES2015.20.5.21025
Publication status	Published - 2015

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SDG 3 Good Health and Well-being

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10.2807/1560-7917.ES2015.20.5.21025

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Pebody, R., Warburton, F., Ellis, J., Andrews, N., Thompson, C., Wissmann, B. V., Green, H., Cottrell, S., Johnston, J., De Lusignan, S., Moore, C., Gunson, R., Robertson, C., McMenamin, J., & Zambon, M. (2015). Low effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 mid–season results. Eurosurveillance, 20(5), 1-7. https://doi.org/10.2807/1560-7917.ES2015.20.5.21025

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title = "Low effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 mid–season results",

abstract = "In 2014/15 the United Kingdom experienced circulation of influenza A(H3N2) with impact in the elderly. Midseason vaccine effectiveness (VE) shows an adjusted VE of 3.4\% (95\% CI: −44.8 to 35.5) against primary care consultation with laboratory-confirmed influenza and −2.3\% (95\% CI: −56.2 to 33.0) for A(H3N2). The low VE reflects mismatch between circulating viruses and the 2014/15 northern hemisphere A(H3N2) vaccine strain. Early use of antivirals for prophylaxis and treatment of vulnerable populations remains important.",

author = "Richard Pebody and F. Warburton and Joanna Ellis and Nicholas Andrews and Catherine Thompson and Wissmann, \{B. Von\} and Helen Green and S. Cottrell and J. Johnston and \{De Lusignan\}, S. and C. Moore and R. Gunson and C. Robertson and J. McMenamin and Maria Zambon",

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Pebody, R, Warburton, F, Ellis, J, Andrews, N , Thompson, C, Wissmann, BV, Green, H, Cottrell, S, Johnston, J, De Lusignan, S, Moore, C, Gunson, R, Robertson, C, McMenamin, J & Zambon, M 2015, 'Low effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 mid–season results', Eurosurveillance, vol. 20, no. 5, pp. 1-7. https://doi.org/10.2807/1560-7917.ES2015.20.5.21025

TY - JOUR

T1 - Low effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom

T2 - 2014/15 mid–season results

AU - Pebody, Richard

AU - Warburton, F.

AU - Ellis, Joanna

AU - Andrews, Nicholas

AU - Thompson, Catherine

AU - Wissmann, B. Von

AU - Green, Helen

AU - Cottrell, S.

AU - Johnston, J.

AU - De Lusignan, S.

AU - Moore, C.

AU - Gunson, R.

AU - Robertson, C.

AU - McMenamin, J.

AU - Zambon, Maria

PY - 2015

Y1 - 2015

N2 - In 2014/15 the United Kingdom experienced circulation of influenza A(H3N2) with impact in the elderly. Midseason vaccine effectiveness (VE) shows an adjusted VE of 3.4% (95% CI: −44.8 to 35.5) against primary care consultation with laboratory-confirmed influenza and −2.3% (95% CI: −56.2 to 33.0) for A(H3N2). The low VE reflects mismatch between circulating viruses and the 2014/15 northern hemisphere A(H3N2) vaccine strain. Early use of antivirals for prophylaxis and treatment of vulnerable populations remains important.

AB - In 2014/15 the United Kingdom experienced circulation of influenza A(H3N2) with impact in the elderly. Midseason vaccine effectiveness (VE) shows an adjusted VE of 3.4% (95% CI: −44.8 to 35.5) against primary care consultation with laboratory-confirmed influenza and −2.3% (95% CI: −56.2 to 33.0) for A(H3N2). The low VE reflects mismatch between circulating viruses and the 2014/15 northern hemisphere A(H3N2) vaccine strain. Early use of antivirals for prophylaxis and treatment of vulnerable populations remains important.

UR - https://www.scopus.com/pages/publications/84922806328

U2 - 10.2807/1560-7917.ES2015.20.5.21025

DO - 10.2807/1560-7917.ES2015.20.5.21025

M3 - Article

C2 - 602268014

AN - SCOPUS:84922806328

SN - 1025-496X

VL - 20

SP - 1

EP - 7

JO - Eurosurveillance

JF - Eurosurveillance

IS - 5

ER -

Low effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 mid–season results

Abstract

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