Abstract
Any potential positive effects conferred via sunlight exposure have to be carefully balanced against carcinogenic effects. Here we provide evidence UK sunlight exposure upregulates the cardio protectant nitric oxide (NO) within in vitro skin cell lines with negligible increases in DNA damage and cell death at 1 SED, when compared against unexposed samples. The whole of the ultraviolet A (UV-A) spectrum appears to be responsible for NO release, with efficiency higher at exposures closer to shorter UV-A wavelengths and decreasing with wavelength increases. These results support further in vivo work, which could be of benefit for demographics such as the elderly (that exhibit a natural decline in NO bioavailability).
| Original language | English |
|---|---|
| Article number | 16306 |
| Journal | Scientific Reports |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 2023 |
Bibliographical note
Funding Information:This study is part funded by the National Institute for Health Research (NIHR) Health Protection Research Unit in Chemical and Radiation Treats and Hazards, a partnership between UK Health Security Agency and Imperial College London. The views expressed are those of the authors and not necessarily those of the NIHR, UKHSA or the Department of Health and Social Care. The authors also would like to thank Phil Miles of UKHSA for the design and construction of temperature-controlled stage which was critical for consistency of outdoor experiments.
Funding Information:
This study is part funded by the National Institute for Health Research (NIHR) Health Protection Research Unit in Chemical and Radiation Treats and Hazards, a partnership between UK Health Security Agency and Imperial College London. The views expressed are those of the authors and not necessarily those of the NIHR, UKHSA or the Department of Health and Social Care. The authors also would like to thank Phil Miles of UKHSA for the design and construction of temperature-controlled stage which was critical for consistency of outdoor experiments.
Publisher Copyright:
© 2023, Springer Nature Limited.