Live attenuated influenza vaccine (LAIV): Recent effectiveness results from the USA and implications for LAIV programmes elsewhere

Richard Pebody*, Jim McMenamin, Hanna Nohynek

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    49 Citations (Scopus)

    Abstract

    The USA has a long-standing paediatric influenza vaccination programme, including use of live attenuated influenza vaccine (LAIV). Following US evidence of apparent lack of vaccine effectiveness (VE) of LAIV in 2015/2016, particularly against A(H1N1)pdm09, the USA suspended the use of LAIV in the 2016/2017 season. The UK introduced LAIV for children in 2013/2014 and Finland in 2015/2016. Both countries have since been closely monitoring programme performance. In 2015/2016, the UK and Finland, unlike the USA, found evidence of significant VE of LAIV against laboratory-confirmed influenza. Several studies, however, reported relatively lower VE of LAIV against A(H1N1)pdm09 infection compared with inactivated influenza vaccine, although not for A(H3N2) or B. The reasons for these apparent differences remain under investigation. Both the UK and Finland continue to recommend the use of LAIV in children for the 2017/2018 season and are intensifying further monitoring of their childhood programmes against a range of end-points.

    Original languageEnglish
    Pages (from-to)101-105
    Number of pages5
    JournalArchives of Disease in Childhood
    Volume103
    Issue number1
    DOIs
    Publication statusPublished - 2018

    Fingerprint

    Dive into the research topics of 'Live attenuated influenza vaccine (LAIV): Recent effectiveness results from the USA and implications for LAIV programmes elsewhere'. Together they form a unique fingerprint.

    Cite this