Lineage-dependent differences of Zika virus infection in a susceptible mouse model are associated with different profiles of cytokines, chemokines, growth factors and acute phase proteins

Stuart Dowall*, Victoria A. Graham, Roger Hewson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Zika virus (ZIKV) is phylogenetically divided into two lineages comprising African (ZIKVAF) and Asian (ZIKVAS) genotypes. In the type-I interferon receptor deficient mouse model, ZIKVAF causes severe disease with all mice meeting humane endpoints with doses as low as 10 plaque-forming units (pfu) whereas a much milder infection is seen after challenge with ZIKVAS, including with doses as high as 106 pfu. Using this mouse model, the elucidation of cytokine, chemokine, growth factor and acute phase protein responses over the course of infection were studied to determine whether these analytes contributed to the stark difference in clinical outcome. Results demonstrated some significant differences, with the ZIKVAF infection being associated with increases in a higher number of biomarkers than ZIKVAS. When low (10 pfu) and high (106 pfu) challenge doses were compared, animals given the lower virus inoculum showed a wider range of responses, indicating a different disease progression compared to those challenged with high doses. These results aid with elucidating the different outcomes with the two lineages of ZIKV and with future work to assess pathogenicity of virus infection.

Original languageEnglish
Article number154864
JournalCytokine
Volume125
Early online date29 Sep 2019
DOIs
Publication statusPublished - Jan 2020

Bibliographical note

Funding Information: Work was funded through the Public Health England grant-in-aid programmes.

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Open Access: No Open Access licence

Publisher Copyright: Crown Copyright © 2019 Published by Elsevier Ltd. All rights reserved.

Citation: Stuart D. Dowall, Victoria A. Graham, Roger Hewson, Lineage-dependent differences of Zika virus infection in a susceptible mouse model are associated with different profiles of cytokines, chemokines, growth factors and acute phase proteins, Cytokine, Volume 125, 2020, 154864, ISSN 1043-4666,

DOI: https://doi.org/10.1016/j.cyto.2019.154864.

Keywords

  • Acute phase proteins
  • Chemokine
  • Cytokine
  • Growth factors
  • Pathogenicity
  • Zika virus

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