Life-threatening parvovirus B19 - Associated myocarditis and cardiac transplantation as possible therapy: Two case reports

G. Enders; J. Dötsch; J. Bauer; W. Nützenadel; H. Hengel; D. Haffner; G. Schalasta; K. Searle; K. E. Brown

doi:10.1086/516295

Life-threatening parvovirus B19 - Associated myocarditis and cardiac transplantation as possible therapy: Two case reports

G. Enders^*, J. Dötsch, J. Bauer, W. Nützenadel, H. Hengel, D. Haffner, G. Schalasta, K. Searle, K. E. Brown

^*Corresponding author for this work

Immunisation Hepatitis and Blood Safety

Research output: Contribution to journal › Article › peer-review

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Abstract

Parvovirus B19 infection can cause a wide spectrum of disease syndromes. Two cases of parvovirus B 19 infection were identified that resulted in life- threatening myocarditis shortly after acute infection in immunocompetent individuals. The diagnosis was made with serological and polymerase chain reaction techniques. One patient was successfully treated by heart transplantation. Sequence analysis showed that the parvovirus B19 cloned from the patients' sera had 99% homology with the prototype sequence. Clinicians should be alerted to the possible role of parvovirus B19 in myocarditis presenting in immunocompetent patients.

Original language	English
Pages (from-to)	355-358
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	26
Issue number	2
DOIs	https://doi.org/10.1086/516295
Publication status	Published - 1998

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10.1086/516295

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title = "Life-threatening parvovirus B19 - Associated myocarditis and cardiac transplantation as possible therapy: Two case reports",

abstract = "Parvovirus B19 infection can cause a wide spectrum of disease syndromes. Two cases of parvovirus B 19 infection were identified that resulted in life- threatening myocarditis shortly after acute infection in immunocompetent individuals. The diagnosis was made with serological and polymerase chain reaction techniques. One patient was successfully treated by heart transplantation. Sequence analysis showed that the parvovirus B19 cloned from the patients' sera had 99% homology with the prototype sequence. Clinicians should be alerted to the possible role of parvovirus B19 in myocarditis presenting in immunocompetent patients.",

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AU - Enders, G.

AU - Dötsch, J.

AU - Bauer, J.

AU - Nützenadel, W.

AU - Hengel, H.

AU - Haffner, D.

AU - Schalasta, G.

AU - Searle, K.

AU - Brown, K. E.

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AB - Parvovirus B19 infection can cause a wide spectrum of disease syndromes. Two cases of parvovirus B 19 infection were identified that resulted in life- threatening myocarditis shortly after acute infection in immunocompetent individuals. The diagnosis was made with serological and polymerase chain reaction techniques. One patient was successfully treated by heart transplantation. Sequence analysis showed that the parvovirus B19 cloned from the patients' sera had 99% homology with the prototype sequence. Clinicians should be alerted to the possible role of parvovirus B19 in myocarditis presenting in immunocompetent patients.

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

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ER -

Life-threatening parvovirus B19 - Associated myocarditis and cardiac transplantation as possible therapy: Two case reports

Abstract

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