Letermovir salvage therapy in the management of a case of cytomegalovirus ventriculitis complicated by drug resistance

Andrew Bosworth; Sowsan F. Atabani; Anastasia Theodosiou; Avneet Shahi; Tatiana Peate; Steven Wilson; Emanuela Pelosi; Andrew Rosser

doi:10.1016/j.clinpr.2020.100039

Letermovir salvage therapy in the management of a case of cytomegalovirus ventriculitis complicated by drug resistance

Andrew Bosworth, Sowsan F. Atabani, Anastasia Theodosiou, Avneet Shahi, Tatiana Peate, Steven Wilson, Emanuela Pelosi, Andrew Rosser^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Reported is a case of cytomegalovirus ventriculitis on a background of HIV infection. Sequencing demonstrated viral mutations conferring resistance to available therapies. Compassionate use of letermovir was attempted; though clinical improvement was observed the patient passed away. Sequencing demonstrated that known letermovir resistance mutations were not detected in this virus.

Original language	English
Article number	100039
Journal	Clinical Infection in Practice
Volume	7-8
DOIs	https://doi.org/10.1016/j.clinpr.2020.100039
Publication status	Published - Oct 2020

Bibliographical note

Publisher Copyright:
© 2020

Keywords

Clinical virology
Cytomegalovirus
Drug resistance
Human immunodeficiency virus
Immunocompromised
Letermovir

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clinpr.2020.100039

Cite this

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title = "Letermovir salvage therapy in the management of a case of cytomegalovirus ventriculitis complicated by drug resistance",

abstract = "Reported is a case of cytomegalovirus ventriculitis on a background of HIV infection. Sequencing demonstrated viral mutations conferring resistance to available therapies. Compassionate use of letermovir was attempted; though clinical improvement was observed the patient passed away. Sequencing demonstrated that known letermovir resistance mutations were not detected in this virus.",

keywords = "Clinical virology, Cytomegalovirus, Drug resistance, Human immunodeficiency virus, Immunocompromised, Letermovir",

author = "Andrew Bosworth and Atabani, {Sowsan F.} and Anastasia Theodosiou and Avneet Shahi and Tatiana Peate and Steven Wilson and Emanuela Pelosi and Andrew Rosser",

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year = "2020",

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doi = "10.1016/j.clinpr.2020.100039",

language = "English",

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journal = "Clinical Infection in Practice",

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T1 - Letermovir salvage therapy in the management of a case of cytomegalovirus ventriculitis complicated by drug resistance

AU - Bosworth, Andrew

AU - Atabani, Sowsan F.

AU - Theodosiou, Anastasia

AU - Shahi, Avneet

AU - Peate, Tatiana

AU - Wilson, Steven

AU - Pelosi, Emanuela

AU - Rosser, Andrew

PY - 2020/10

Y1 - 2020/10

N2 - Reported is a case of cytomegalovirus ventriculitis on a background of HIV infection. Sequencing demonstrated viral mutations conferring resistance to available therapies. Compassionate use of letermovir was attempted; though clinical improvement was observed the patient passed away. Sequencing demonstrated that known letermovir resistance mutations were not detected in this virus.

AB - Reported is a case of cytomegalovirus ventriculitis on a background of HIV infection. Sequencing demonstrated viral mutations conferring resistance to available therapies. Compassionate use of letermovir was attempted; though clinical improvement was observed the patient passed away. Sequencing demonstrated that known letermovir resistance mutations were not detected in this virus.

KW - Clinical virology

KW - Cytomegalovirus

KW - Drug resistance

KW - Human immunodeficiency virus

KW - Immunocompromised

KW - Letermovir

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U2 - 10.1016/j.clinpr.2020.100039

DO - 10.1016/j.clinpr.2020.100039

M3 - Article

AN - SCOPUS:85121057940

SN - 2590-1702

VL - 7-8

JO - Clinical Infection in Practice

JF - Clinical Infection in Practice

M1 - 100039

ER -

Letermovir salvage therapy in the management of a case of cytomegalovirus ventriculitis complicated by drug resistance

Abstract

Bibliographical note

Keywords

UN SDGs

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