Lack of association between screencell-detected circulating tumour cells and long-term survival of patients undergoing surgery for non-small cell lung cancer: A pilot clinical study

James Barr, Dimple Chudasama, Alex Rice, Emmanouil Karteris, Vladimir Anikin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Circulating tumour cells (CTCs) are cancer cells of epithelial origin that are present in peripheral blood samples. ScreenCell detection of CTCs and the association with long term survival in non-small cell lung cancer (NSCLC) patients was evaluated in the present study. A total of 33 patients undergoing surgical resection for NSCLC were recruited. Patients were followed up for 5-years post-operatively. Pre-operative patient bloods samples were processed using ScreenCell. CTCs were detected in 26 (79%) patients. In patients who were positive for CTCs, a total of 9 (35%) patients succumbed to the disease, whereas in patients negative for CTCs, a total of 4 (57%) patients succumbed to the disease (P=0.29). No association was identified between positive CTCs and poorer survival (Chi-squared 1.47, P=0.23; hazard ratio, 0.42; 95% confidence interval: 0.1-1.7). The presence of CTCs detected with ScreenCell does not influence prognosis in patients with NSCLC that was operated on. The high rate of CTC detection is encouraging in supporting this technology to aid early lung cancer diagnosis.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalMolecular and Clinical Oncology
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 2020
Externally publishedYes

Bibliographical note

Funding Information:
The present study was supported by funding was from The Harefield Charitable Cryotherapy Trust Funds.

Publisher Copyright:
© 2020, Spandidos Publications. All rights reserved.

Keywords

  • Circulating tumour cells
  • Lung cancer
  • Screen cell

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