Klebsiella pneumoniae producing KPC carbapenemase in a district general hospital in the UK

N. Virgincar; S. Iyer; A. Stacey; S. Maharjan; Rachel Pike; C. Perry; J. Wyeth; Neil Woodford

doi:10.1016/j.jhin.2011.03.016

Klebsiella pneumoniae producing KPC carbapenemase in a district general hospital in the UK

N. Virgincar^*
, S. Iyer
, A. Stacey
, S. Maharjan
, Rachel Pike
, C. Perry
, J. Wyeth
, Neil Woodford

^*Corresponding author for this work

Chief Scientific Officer Group Office

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

We report two patients with multidrug-resistant KPC-carbapenemase-producing Klebsiella pneumoniae urinary tract infections. A bla_KPC-2 gene was detected in both of the isolates by polymerase chain reaction and sequencing. The isolates had identical pulsed-field gel electrophoresis patterns and belonged to sequence type ST11. The index patient probably acquired the KPC-producing strain while in hospital in Curaçao, with subsequent nosocomial transmission to the second patient occurring in our hospital. We describe the interventions that were taken to prevent its further spread within the acute Trust and the community.

Original language	English
Pages (from-to)	293-296
Number of pages	4
Journal	Journal of Hospital Infection
Volume	78
Issue number	4
DOIs	https://doi.org/10.1016/j.jhin.2011.03.016
Publication status	Published - Aug 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

KPC carbapenemase
Klebsiella pneumoniae
Polymerase chain reaction

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10.1016/j.jhin.2011.03.016

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title = "Klebsiella pneumoniae producing KPC carbapenemase in a district general hospital in the UK",

abstract = "We report two patients with multidrug-resistant KPC-carbapenemase-producing Klebsiella pneumoniae urinary tract infections. A blaKPC-2 gene was detected in both of the isolates by polymerase chain reaction and sequencing. The isolates had identical pulsed-field gel electrophoresis patterns and belonged to sequence type ST11. The index patient probably acquired the KPC-producing strain while in hospital in Cura{\c c}ao, with subsequent nosocomial transmission to the second patient occurring in our hospital. We describe the interventions that were taken to prevent its further spread within the acute Trust and the community.",

keywords = "KPC carbapenemase, Klebsiella pneumoniae, Polymerase chain reaction",

author = "N. Virgincar and S. Iyer and A. Stacey and S. Maharjan and Rachel Pike and C. Perry and J. Wyeth and Neil Woodford",

year = "2011",

month = aug,

doi = "10.1016/j.jhin.2011.03.016",

language = "English",

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journal = "Journal of Hospital Infection",

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T1 - Klebsiella pneumoniae producing KPC carbapenemase in a district general hospital in the UK

AU - Virgincar, N.

AU - Iyer, S.

AU - Stacey, A.

AU - Maharjan, S.

AU - Pike, Rachel

AU - Perry, C.

AU - Wyeth, J.

AU - Woodford, Neil

PY - 2011/8

Y1 - 2011/8

N2 - We report two patients with multidrug-resistant KPC-carbapenemase-producing Klebsiella pneumoniae urinary tract infections. A blaKPC-2 gene was detected in both of the isolates by polymerase chain reaction and sequencing. The isolates had identical pulsed-field gel electrophoresis patterns and belonged to sequence type ST11. The index patient probably acquired the KPC-producing strain while in hospital in Curaçao, with subsequent nosocomial transmission to the second patient occurring in our hospital. We describe the interventions that were taken to prevent its further spread within the acute Trust and the community.

AB - We report two patients with multidrug-resistant KPC-carbapenemase-producing Klebsiella pneumoniae urinary tract infections. A blaKPC-2 gene was detected in both of the isolates by polymerase chain reaction and sequencing. The isolates had identical pulsed-field gel electrophoresis patterns and belonged to sequence type ST11. The index patient probably acquired the KPC-producing strain while in hospital in Curaçao, with subsequent nosocomial transmission to the second patient occurring in our hospital. We describe the interventions that were taken to prevent its further spread within the acute Trust and the community.

KW - KPC carbapenemase

KW - Klebsiella pneumoniae

KW - Polymerase chain reaction

UR - https://www.scopus.com/pages/publications/79960155262

U2 - 10.1016/j.jhin.2011.03.016

DO - 10.1016/j.jhin.2011.03.016

M3 - Article

C2 - 21641083

AN - SCOPUS:79960155262

SN - 0195-6701

VL - 78

SP - 293

EP - 296

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

IS - 4

ER -

Klebsiella pneumoniae producing KPC carbapenemase in a district general hospital in the UK

Abstract

UN SDGs

Keywords

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