Kinetics of the neutralizing antibody response to respiratory syncytial virus infections in a birth cohort

C. J. Sande*, M. N. Mutunga, E. A. Okiro, G. F. Medley, Patricia Cane, D. J. Nokes

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    29 Citations (Scopus)


    The kinetics of respiratory syncytial virus (RSV) neutralizing antibodies following birth, primary and secondary infections are poorly defined. The aims of the study were to measure and compare neutralizing antibody responses at different time points in a birth cohort followed-up over three RSV epidemics. Rural Kenyan children, recruited at birth between 2002 and 2003, were monitored for RSV infection over three epidemic seasons. Cord and 3-monthly sera, and acute and convalescent sera following RSV infection, were assayed in 28 children by plaque reduction neutralization test (PRNT). Relative to the neutralizing antibody titers of pre-exposure control sera (1.8log10 PRNT), antibody titers following primary infection were (i) no different in sera collected between 0 and 0.4 months post-infection (1.9log10 PRNT, P=0.146), (ii) higher in sera collected between 0.5 and 0.9 (2.8log10 PRNT, P<0.0001), 1.0-1.9 (2.5log10 PRNT, P<0.0001), and 2.0-2.9 (2.3log10 PRNT, P<0.001) months post-infection, and (iii) no different in sera collected at between 3.0 and 3.9 months post-infection (2.0log10 PRNT, P=0.052). The early serum neutralizing response to secondary infection (3.02log10 PRNT) was significantly greater than the early primary response (1.9log10 PRNT, P<0.0001). Variation in population-level virus transmission corresponded with changes in the mean cohort-level neutralizing titers. It is concluded that following primary RSV infection the neutralizing antibody response declines to pre-infection levels rapidly (∼3 months) which may facilitate repeat infection. The kinetics of the aggregate levels of acquired antibody reflect seasonal RSV occurrence, age, and infection history.

    Original languageEnglish
    Pages (from-to)2020-2025
    Number of pages6
    JournalJournal of Medical Virology
    Issue number11
    Publication statusPublished - Nov 2013


    • Immunity
    • Neutralizing antibody dynamics
    • RSV


    Dive into the research topics of 'Kinetics of the neutralizing antibody response to respiratory syncytial virus infections in a birth cohort'. Together they form a unique fingerprint.

    Cite this