Kinetics of the natural, humoral immune response to Salmonella enterica serovar Typhi in Kathmandu, Nepal

Anoop S. Pulickal, Samir Gautam, Elizabeth A. Clutterbuck, Stephen Thorson, Buddha Basynat, Neelam Adhikari, Katherine Makepeace, Sjoerd Rijpkema, Ray Borrow, Jeremy J. Farrar, Andrew J. Pollard

    Research output: Contribution to journalArticlepeer-review

    46 Citations (Scopus)

    Abstract

    Typhoid fever is a major public health problem in developing countries, conservatively estimated to occur in 17 million cases and be responsible for 200,000 deaths annually. We investigated the acquisition of natural immunity to Salmonella enterica serovar Typhi in a region where typhoid is endemic by testing sera from an age-stratified sample of 210 healthy participants in Kathmandu, Nepal, for bactericidal activity toward S. Typhi and for anti-Vi capsular polysaccharide antibodies. Bactericidal titers in children were significantly lower than those in newborns and adults (P < 0.0001). Anti-S. Typhi bactericidal geometric mean titers were age dependent, increasing 10-fold during childhood. Anti-Vi polysaccharide antibody geometric mean concentrations were also lower in children than in adults. Data presented here indicate the possibility of a relationship between low levels of bactericidal activity toward S. Typhi in serum and susceptibility to disease, as observed for other polysaccharide-encapsulated bacteria. Bactericidal antibody may be a marker of protective immunity against S. Typhi.

    Original languageEnglish
    Pages (from-to)1413-1419
    Number of pages7
    JournalClinical and Vaccine Immunology
    Volume16
    Issue number10
    DOIs
    Publication statusPublished - Oct 2009

    Fingerprint

    Dive into the research topics of 'Kinetics of the natural, humoral immune response to Salmonella enterica serovar Typhi in Kathmandu, Nepal'. Together they form a unique fingerprint.

    Cite this