Is the HCV-HIV co-infection prevalence amongst injecting drug users a marker for the level of sexual and injection related HIV transmission?

Peter Vickerman*, Natasha K. Martin, Anuradha Roy, Tara Beattie, Don Des Jarlais, Steffanie Strathdee, Lucas Wiessing, Matthew Hickman, Y. P. Bao, Waleska Caiaffa, Gonzalo Ralón, Diana Rossi, Laura Camoni, Barbara Suligoi, Nejc Bergant, Peer Brehm Christensen, Óscar Duarte, Sofia Santos, Carla Ribeiro, Ksenia EritsyanVeronika Odinokova, Konstantin Vyshinsky, Cinta Folch, Jordi Casabona, Anastasios Fotiou, Vivian Hope, Ilonka Horvath, Sharon Hutchinson, Violeta Bogdanova, Raina Ilieva, Jean Long, Catharina Matheï, Alexandr Muravsky, Leonie Prasad, Henrique Barros, Magdalena Rosinska, Marie Jauffret Roustide, Otilia Scutelniciuc, Fernando Vallejo, Uusküla Anneli, Bruno Guarita, Andre Noor, Luis de la Fuente, Marc Roelands, Michaël Hogge

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Background: Amongst injecting drug users (IDUs), HIV is transmitted sexually and parenterally, but HCV is transmitted primarily parenterally. We assess and model the antibody prevalence of HCV amongst HIV-infected IDUs (denoted as HCV-HIV co-infection prevalence) and consider whether it proxies the degree of sexual HIV transmission amongst IDUs. Methods: HIV, HCV and HCV-HIV co-infection prevalence data amongst IDU was reviewed. An HIV/HCV transmission model was adapted. Multivariate model uncertainty analyses determined whether the model's ability to replicate observed data trends required the inclusion of sexual HIV transmission. The correlation between the model's HCV-HIV co-infection prevalence and estimated proportion of HIV infections due to injecting was evaluated. Results: The median HCV-HIV co-infection prevalence (prevalence of HCV amongst HIV-infected IDUs) was 90% across 195 estimates from 43 countries. High HCV-HIV co-infection prevalences (>80%) occur in most (75%) settings, but can be lower in settings with low HIV prevalence (<10%) or high HIV/HCV prevalence ratios (HIV prevalence divided by HCV prevalence > 0.75). The model without sexual HIV transmission reproduced some data trends but could not reproduce any epidemics with high HIV/HCV prevalence ratios (>0.85) or low HCV-HIV co-infection prevalence (<60%) when HIV prevalence > 10%. The model with sexual HIV transmission reproduced data trends more closely. The proportion of HIV infections due to injecting correlated with HCV-HIV co-infection prevalence; suggesting that up to 80/60/<20% of HIV infections could be sexually transmitted in settings with HCV-HIV co-infection prevalence between 50-60/70-80/>90%. Conclusion: Substantial sexual HIV transmission may occur in many IDU populations; HCV-HIV co-infection prevalence could signify its importance.

Original languageEnglish
Pages (from-to)172-181
Number of pages10
JournalDrug and Alcohol Dependence
Volume132
Issue number1-2
DOIs
Publication statusPublished - 1 Sep 2013

Bibliographical note

Funding Information:
PV is funded by a MRC New Investigators Award (G0701627) and the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) . MH is funded by NCCRCD/NIHR and LW is funded by EMCDDA. The contribution of NKM is under the terms of her postdoctoral research training fellowship issued by the NIHR. The MRC, EMCDDA, NCCRCD and NIHR had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. The views expressed in this publication are those of the authors and not necessarily those of the NHS, The National Institute for Health Research, MRC, EMCDDA, LSHTM or the Department of Health.

Keywords

  • Co-infection
  • Hepatitis C
  • HIV
  • Injecting drug use
  • Modelling

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