TY - JOUR
T1 - Ionizing radiation-induced DNA strand breaks and γ-H2AXγ-H2AX foci in cells exposed to nitric oxide.
AU - Rothkamm, Kai
AU - Burdak-Rothkamm, Susanne
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2011
Y1 - 2011
N2 - A number of studies have demonstrated that nitric oxide enhances radiosensitivity of anoxic and hypoxic cells in vitro and in vivo, and some evidence points to a role for DNA damage and repair in this phenomenon. We have recently observed that nitric oxide enhances the formation of DNA single- and double-strand breaks following ionising irradiation, measured by the alkaline comet assay and immunofluorescence microscopy for γ-H2AXγ-H2AX.
AB - A number of studies have demonstrated that nitric oxide enhances radiosensitivity of anoxic and hypoxic cells in vitro and in vivo, and some evidence points to a role for DNA damage and repair in this phenomenon. We have recently observed that nitric oxide enhances the formation of DNA single- and double-strand breaks following ionising irradiation, measured by the alkaline comet assay and immunofluorescence microscopy for γ-H2AXγ-H2AX.
UR - http://www.scopus.com/inward/record.url?scp=79955666421&partnerID=8YFLogxK
U2 - 10.1007/978-1-61737-964-2_2
DO - 10.1007/978-1-61737-964-2_2
M3 - Article
C2 - 21161626
AN - SCOPUS:79955666421
SN - 1064-3745
VL - 704
SP - 17
EP - 25
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
ER -