TY - JOUR
T1 - Ionising radiation and risk of death from leukaemia and lymphoma in radiation-monitored workers (INWORKS)
T2 - An international cohort study
AU - Leuraud, Klervi
AU - Richardson, David B.
AU - Cardis, Elisabeth
AU - Daniels, Robert D.
AU - Gillies, Michael
AU - O'Hagan, Jacqueline A.
AU - Hamra, Ghassan B.
AU - Haylock, Richard
AU - Laurier, Dominique
AU - Moissonnier, Monika
AU - Schubauer-Berigan, Mary K.
AU - Thierry-Chef, Isabelle
AU - Kesminiene, Ausrele
N1 - Publisher Copyright:
© 2015 Leuraud et al. Open Access article distributed under the terms of CC BY-NC-ND.
PY - 2015
Y1 - 2015
N2 - Background: There is much uncertainty about the risks of leukaemia and lymphoma after repeated or protracted low-dose radiation exposure typical of occupational, environmental, and diagnostic medical settings. We quantified associations between protracted low-dose radiation exposures and leukaemia, lymphoma, and multiple myeloma mortality among radiation-monitored adults employed in France, the UK, and the USA. Methods: We assembled a cohort of 308 297 radiation-monitored workers employed for at least 1 year by the Atomic Energy Commission, AREVA Nuclear Cycle, or the National Electricity Company in France, the Departments of Energy and Defence in the USA, and nuclear industry employers included in the National Registry for Radiation Workers in the UK. The cohort was followed up for a total of 8·22 million person-years. We ascertained deaths caused by leukaemia, lymphoma, and multiple myeloma. We used Poisson regression to quantify associations between estimated red bone marrow absorbed dose and leukaemia and lymphoma mortality. Findings: Doses were accrued at very low rates (mean 1·1 mGy per year, SD 2·6). The excess relative risk of leukaemia mortality (excluding chronic lymphocytic leukaemia) was 2·96 per Gy (90% CI 1·17-5·21; lagged 2 years), most notably because of an association between radiation dose and mortality from chronic myeloid leukaemia (excess relative risk per Gy 10·45, 90% CI 4·48-19·65). Interpretation: This study provides strong evidence of positive associations between protracted low-dose radiation exposure and leukaemia. Funding: Centers for Disease Control and Prevention, Ministry of Health, Labour and Welfare of Japan, Institut de Radioprotection et de SÛreté Nucléaire, AREVA, Electricité de France, National Institute for Occupational Safety and Health, US Department of Energy, US Department of Health and Human Services, University of North Carolina, Public Health England.
AB - Background: There is much uncertainty about the risks of leukaemia and lymphoma after repeated or protracted low-dose radiation exposure typical of occupational, environmental, and diagnostic medical settings. We quantified associations between protracted low-dose radiation exposures and leukaemia, lymphoma, and multiple myeloma mortality among radiation-monitored adults employed in France, the UK, and the USA. Methods: We assembled a cohort of 308 297 radiation-monitored workers employed for at least 1 year by the Atomic Energy Commission, AREVA Nuclear Cycle, or the National Electricity Company in France, the Departments of Energy and Defence in the USA, and nuclear industry employers included in the National Registry for Radiation Workers in the UK. The cohort was followed up for a total of 8·22 million person-years. We ascertained deaths caused by leukaemia, lymphoma, and multiple myeloma. We used Poisson regression to quantify associations between estimated red bone marrow absorbed dose and leukaemia and lymphoma mortality. Findings: Doses were accrued at very low rates (mean 1·1 mGy per year, SD 2·6). The excess relative risk of leukaemia mortality (excluding chronic lymphocytic leukaemia) was 2·96 per Gy (90% CI 1·17-5·21; lagged 2 years), most notably because of an association between radiation dose and mortality from chronic myeloid leukaemia (excess relative risk per Gy 10·45, 90% CI 4·48-19·65). Interpretation: This study provides strong evidence of positive associations between protracted low-dose radiation exposure and leukaemia. Funding: Centers for Disease Control and Prevention, Ministry of Health, Labour and Welfare of Japan, Institut de Radioprotection et de SÛreté Nucléaire, AREVA, Electricité de France, National Institute for Occupational Safety and Health, US Department of Energy, US Department of Health and Human Services, University of North Carolina, Public Health England.
UR - http://www.scopus.com/inward/record.url?scp=84955727470&partnerID=8YFLogxK
U2 - 10.1016/S2352-3026(15)00094-0
DO - 10.1016/S2352-3026(15)00094-0
M3 - Article
C2 - 26436129
AN - SCOPUS:84955727470
SN - 2352-3026
VL - 2
SP - e276-e281
JO - The Lancet Haematology
JF - The Lancet Haematology
IS - 7
ER -