Investigations of the potential bioavailability of 210Po in some foodstuffs

Robert Bulman; Leon W. Ewers; Kiyoshi Matsumoto

doi:10.1016/0048-9697(95)04740-9

Investigations of the potential bioavailability of ²¹⁰Po in some foodstuffs

Robert Bulman^*, Leon W. Ewers, Kiyoshi Matsumoto

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Extraction of ²¹⁰Po from lamb's liver, pig's kidneys, mussel flesh and brown crabmeat with a series of solvent systems has been used to gain some insight into the uncertainty about the gastrointestinal absorption factor for Po incorporated into foodstuffs. By extracting the tissues with diethyldithiocarbamate dissolved in chloroform, and also in methanol, it has been shown that ²¹⁰Po is more effectively extracted from lamb's liver and crabmeat than it is from each of the other tissues. A similar pattern of extractability is also evident for aqueous solutions of citric acid on crabmeat and mussel flesh. Of particular note is the low extractability by dimethylsulphoxide (3%) of ²¹⁰Po in mussel flesh as opposed to 24% extractability of ²¹⁰Po from crabmeat. ²¹⁰Po-binding macromolecules of about 10 kDa have been released from crabmeat and mussel flesh by digestion with pepsin.

Original language	English
Pages (from-to)	151-158
Number of pages	8
Journal	Science of the Total Environment, The
Volume	173-174
Issue number	C
DOIs	https://doi.org/10.1016/0048-9697(95)04740-9
Publication status	Published - 1 Dec 1995

Bibliographical note

Funding Information:
The synthesis of 2,7-bis-(2’-thiazolyl)-2,7-di-azaoligooxapentadecane (BTDP) was made possible by Grant-in-Aid No. 04453023 from the Ministry of Education, Science and Culture, Japan. The authors are also grateful to the Ministry of Education, Science and Culture, Japan, for purchasing the high-field NMR instruments (JEOL JNM-A500 and JNM-EX270) by the special fund (to K.M. as a representative in 1992).

Keywords

Bioavailability
Chemical form
Polonium

Access to Document

10.1016/0048-9697(95)04740-9

Cite this

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title = "Investigations of the potential bioavailability of 210Po in some foodstuffs",

abstract = "Extraction of 210Po from lamb's liver, pig's kidneys, mussel flesh and brown crabmeat with a series of solvent systems has been used to gain some insight into the uncertainty about the gastrointestinal absorption factor for Po incorporated into foodstuffs. By extracting the tissues with diethyldithiocarbamate dissolved in chloroform, and also in methanol, it has been shown that 210Po is more effectively extracted from lamb's liver and crabmeat than it is from each of the other tissues. A similar pattern of extractability is also evident for aqueous solutions of citric acid on crabmeat and mussel flesh. Of particular note is the low extractability by dimethylsulphoxide (3%) of 210Po in mussel flesh as opposed to 24% extractability of 210Po from crabmeat. 210Po-binding macromolecules of about 10 kDa have been released from crabmeat and mussel flesh by digestion with pepsin.",

keywords = "Bioavailability, Chemical form, Polonium",

author = "Robert Bulman and Ewers, {Leon W.} and Kiyoshi Matsumoto",

note = "Funding Information: The synthesis of 2,7-bis-(2{\textquoteright}-thiazolyl)-2,7-di-azaoligooxapentadecane (BTDP) was made possible by Grant-in-Aid No. 04453023 from the Ministry of Education, Science and Culture, Japan. The authors are also grateful to the Ministry of Education, Science and Culture, Japan, for purchasing the high-field NMR instruments (JEOL JNM-A500 and JNM-EX270) by the special fund (to K.M. as a representative in 1992).",

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AU - Ewers, Leon W.

AU - Matsumoto, Kiyoshi

N1 - Funding Information: The synthesis of 2,7-bis-(2’-thiazolyl)-2,7-di-azaoligooxapentadecane (BTDP) was made possible by Grant-in-Aid No. 04453023 from the Ministry of Education, Science and Culture, Japan. The authors are also grateful to the Ministry of Education, Science and Culture, Japan, for purchasing the high-field NMR instruments (JEOL JNM-A500 and JNM-EX270) by the special fund (to K.M. as a representative in 1992).

PY - 1995/12/1

Y1 - 1995/12/1

N2 - Extraction of 210Po from lamb's liver, pig's kidneys, mussel flesh and brown crabmeat with a series of solvent systems has been used to gain some insight into the uncertainty about the gastrointestinal absorption factor for Po incorporated into foodstuffs. By extracting the tissues with diethyldithiocarbamate dissolved in chloroform, and also in methanol, it has been shown that 210Po is more effectively extracted from lamb's liver and crabmeat than it is from each of the other tissues. A similar pattern of extractability is also evident for aqueous solutions of citric acid on crabmeat and mussel flesh. Of particular note is the low extractability by dimethylsulphoxide (3%) of 210Po in mussel flesh as opposed to 24% extractability of 210Po from crabmeat. 210Po-binding macromolecules of about 10 kDa have been released from crabmeat and mussel flesh by digestion with pepsin.

AB - Extraction of 210Po from lamb's liver, pig's kidneys, mussel flesh and brown crabmeat with a series of solvent systems has been used to gain some insight into the uncertainty about the gastrointestinal absorption factor for Po incorporated into foodstuffs. By extracting the tissues with diethyldithiocarbamate dissolved in chloroform, and also in methanol, it has been shown that 210Po is more effectively extracted from lamb's liver and crabmeat than it is from each of the other tissues. A similar pattern of extractability is also evident for aqueous solutions of citric acid on crabmeat and mussel flesh. Of particular note is the low extractability by dimethylsulphoxide (3%) of 210Po in mussel flesh as opposed to 24% extractability of 210Po from crabmeat. 210Po-binding macromolecules of about 10 kDa have been released from crabmeat and mussel flesh by digestion with pepsin.

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