TY - GEN
T1 - Investigation of motion induced errors in scatter correction for the HRRT brain scanner
AU - Anton-Rodriguez, Jose M.
AU - Sibomana, Merence
AU - Walker, Matthew D.
AU - Huisman, Marc C.
AU - Matthews, Julian C.
AU - Feldmann, Maria
AU - Keller, Sune H.
AU - Asselin, Marie Claude
PY - 2010
Y1 - 2010
N2 - Patient motion during PET scans introduces errors in the attenuation correction and image blurring leading to false changes in regional radioactivity concentrations. However, the potential effect that motion has on simulation-based scatter correction is not fully appreciated. Specifically for tracers with high uptake close to the edge of head (e.g. scalp and nose) as observed with [11C]Verapamil, mismatches between transmission and emission data can lead to significant quantification errors and image artefacts due to over scatter correction. These errors are linked with unusually high values in the scatter scaling factors (SSF) returned during the single scatter simulation process implemented in the HRRT image reconstruction. Reconstruction of -map with TXTV (an alternative -map reconstruction using non-linear filtering rather than brain segmentation and scatter correction of the transmission data) was found to improve the scatter simulation results for [11C] Verapamil and [18F]FDG. The errors from patient motion were characterised and quantified through simulations by applying realistic transformations to the attenuation map (-map). This generated inconsistencies between the emission and transmission data, and introduced large over-corrections of scatter similar to some cases observed with [ 11C]Verapamil. Automated Image Registration (AIR) based motion correction was also implemented, and found to remove the artifact and recover quantification in dynamic studies after aligning all the PET images to a common reference space.
AB - Patient motion during PET scans introduces errors in the attenuation correction and image blurring leading to false changes in regional radioactivity concentrations. However, the potential effect that motion has on simulation-based scatter correction is not fully appreciated. Specifically for tracers with high uptake close to the edge of head (e.g. scalp and nose) as observed with [11C]Verapamil, mismatches between transmission and emission data can lead to significant quantification errors and image artefacts due to over scatter correction. These errors are linked with unusually high values in the scatter scaling factors (SSF) returned during the single scatter simulation process implemented in the HRRT image reconstruction. Reconstruction of -map with TXTV (an alternative -map reconstruction using non-linear filtering rather than brain segmentation and scatter correction of the transmission data) was found to improve the scatter simulation results for [11C] Verapamil and [18F]FDG. The errors from patient motion were characterised and quantified through simulations by applying realistic transformations to the attenuation map (-map). This generated inconsistencies between the emission and transmission data, and introduced large over-corrections of scatter similar to some cases observed with [ 11C]Verapamil. Automated Image Registration (AIR) based motion correction was also implemented, and found to remove the artifact and recover quantification in dynamic studies after aligning all the PET images to a common reference space.
UR - https://www.scopus.com/pages/publications/79960318624
U2 - 10.1109/NSSMIC.2010.5874334
DO - 10.1109/NSSMIC.2010.5874334
M3 - Conference contribution
AN - SCOPUS:79960318624
SN - 9781424491063
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 2935
EP - 2940
BT - IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010
Y2 - 30 October 2010 through 6 November 2010
ER -