Invasive pneumococcal disease in England and Wales: Vaccination implications

Karen Sleeman; Kyle Knox; Robert George; Elizabeth Miller; Pauline Waight; David Griffiths; A. Efstratiou; K. Broughton; Richard T. Mayon-White; E. R. Moxon; D. W. Crook

doi:10.1086/317924

Invasive pneumococcal disease in England and Wales: Vaccination implications

Karen Sleeman
, Kyle Knox
, Robert George
, Elizabeth Miller
, Pauline Waight
, David Griffiths
, A. Efstratiou
, K. Broughton
, Richard T. Mayon-White
, E. R. Moxon
, D. W. Crook

Colindale RSD Ops

Research output: Contribution to journal › Article › peer-review

117 Citations (Scopus)

Abstract

Knowledge of the epidemiology of invasive pneumococcal disease (IPD) will aid in planning the use of pneumococcal vaccines. A United Kingdom (UK)-based surveillance in England and Wales (1995-1997) of 11,528 individuals with IPD and a local enhanced surveillance in the Oxford (UK) area (1995-1999) have been analyzed. IPD has a high attack rate in children, with 37.1-48.1 cases per 100,000 infants <1 year old per year, and in older persons, with 21.2-36.2 cases per 100,000 persons >65 years old per year, for England, Wales, and Oxford. The 7-valent conjugate vaccine includes serotypes causing ≤79% of IPD in children <5 years old, but only 66% in adults >65 years old. The data also indicate that IPD varies by serotype, age, and country, emphasizing that the epidemiology of IPD is heterogeneous and requires continued surveillance.

Original language	English
Pages (from-to)	239-246
Number of pages	8
Journal	Journal of Infectious Diseases
Volume	183
Issue number	2
DOIs	https://doi.org/10.1086/317924
Publication status	Published - 15 Jan 2001

Bibliographical note

Funding Information:
Financial support: Public Health Laboratory Service; University Department of Paediatrics, Oxford, which is funded in part by Aventis Pasteur (to Oxford Vaccine Group).

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10.1086/317924

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title = "Invasive pneumococcal disease in England and Wales: Vaccination implications",

abstract = "Knowledge of the epidemiology of invasive pneumococcal disease (IPD) will aid in planning the use of pneumococcal vaccines. A United Kingdom (UK)-based surveillance in England and Wales (1995-1997) of 11,528 individuals with IPD and a local enhanced surveillance in the Oxford (UK) area (1995-1999) have been analyzed. IPD has a high attack rate in children, with 37.1-48.1 cases per 100,000 infants <1 year old per year, and in older persons, with 21.2-36.2 cases per 100,000 persons >65 years old per year, for England, Wales, and Oxford. The 7-valent conjugate vaccine includes serotypes causing ≤79\% of IPD in children <5 years old, but only 66\% in adults >65 years old. The data also indicate that IPD varies by serotype, age, and country, emphasizing that the epidemiology of IPD is heterogeneous and requires continued surveillance.",

author = "Karen Sleeman and Kyle Knox and Robert George and Elizabeth Miller and Pauline Waight and David Griffiths and A. Efstratiou and K. Broughton and Mayon-White, \{Richard T.\} and Moxon, \{E. R.\} and Crook, \{D. W.\}",

note = "Funding Information: Financial support: Public Health Laboratory Service; University Department of Paediatrics, Oxford, which is funded in part by Aventis Pasteur (to Oxford Vaccine Group).",

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doi = "10.1086/317924",

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T2 - Vaccination implications

AU - Sleeman, Karen

AU - Knox, Kyle

AU - George, Robert

AU - Miller, Elizabeth

AU - Waight, Pauline

AU - Griffiths, David

AU - Efstratiou, A.

AU - Broughton, K.

AU - Mayon-White, Richard T.

AU - Moxon, E. R.

AU - Crook, D. W.

N1 - Funding Information: Financial support: Public Health Laboratory Service; University Department of Paediatrics, Oxford, which is funded in part by Aventis Pasteur (to Oxford Vaccine Group).

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N2 - Knowledge of the epidemiology of invasive pneumococcal disease (IPD) will aid in planning the use of pneumococcal vaccines. A United Kingdom (UK)-based surveillance in England and Wales (1995-1997) of 11,528 individuals with IPD and a local enhanced surveillance in the Oxford (UK) area (1995-1999) have been analyzed. IPD has a high attack rate in children, with 37.1-48.1 cases per 100,000 infants <1 year old per year, and in older persons, with 21.2-36.2 cases per 100,000 persons >65 years old per year, for England, Wales, and Oxford. The 7-valent conjugate vaccine includes serotypes causing ≤79% of IPD in children <5 years old, but only 66% in adults >65 years old. The data also indicate that IPD varies by serotype, age, and country, emphasizing that the epidemiology of IPD is heterogeneous and requires continued surveillance.

AB - Knowledge of the epidemiology of invasive pneumococcal disease (IPD) will aid in planning the use of pneumococcal vaccines. A United Kingdom (UK)-based surveillance in England and Wales (1995-1997) of 11,528 individuals with IPD and a local enhanced surveillance in the Oxford (UK) area (1995-1999) have been analyzed. IPD has a high attack rate in children, with 37.1-48.1 cases per 100,000 infants <1 year old per year, and in older persons, with 21.2-36.2 cases per 100,000 persons >65 years old per year, for England, Wales, and Oxford. The 7-valent conjugate vaccine includes serotypes causing ≤79% of IPD in children <5 years old, but only 66% in adults >65 years old. The data also indicate that IPD varies by serotype, age, and country, emphasizing that the epidemiology of IPD is heterogeneous and requires continued surveillance.

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ER -

Invasive pneumococcal disease in England and Wales: Vaccination implications

Abstract

Bibliographical note

UN SDGs

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