TY - JOUR
T1 - Invasive group A streptococcal disease
T2 - Should close contacts routinely receive antibiotic prophylaxis?
AU - Smith, A.
AU - Lamagni, Theresa
AU - Oliver, Isabel
AU - Efstratiou, Androulla
AU - George, Robert
AU - Stuart, J. M.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/8
Y1 - 2005/8
N2 - Group A streptococci (Streptococcus pyogenes) causes a wide range of illnesses from non-invasive disease - eg, pharyngitis - to more severe invasive infections - eg, necrotising fasciitis and toxic shock-like syndrome. There remains uncertainty about the risk of secondary cases of invasive disease occurring among close contacts of an index case and how best to manage that risk. We do not consider that currently available evidence justifies the routine administration of chemoprophylaxis to close contacts. We suggest that the appropriate response should be to routinely inform all household contacts of a patient with invasive group A streptococcal disease about the clinical manifestations of invasive disease and to seek immediate medical attention if they develop such symptoms.
AB - Group A streptococci (Streptococcus pyogenes) causes a wide range of illnesses from non-invasive disease - eg, pharyngitis - to more severe invasive infections - eg, necrotising fasciitis and toxic shock-like syndrome. There remains uncertainty about the risk of secondary cases of invasive disease occurring among close contacts of an index case and how best to manage that risk. We do not consider that currently available evidence justifies the routine administration of chemoprophylaxis to close contacts. We suggest that the appropriate response should be to routinely inform all household contacts of a patient with invasive group A streptococcal disease about the clinical manifestations of invasive disease and to seek immediate medical attention if they develop such symptoms.
UR - http://www.scopus.com/inward/record.url?scp=22544448726&partnerID=8YFLogxK
U2 - 10.1016/S1473-3099(05)70190-0
DO - 10.1016/S1473-3099(05)70190-0
M3 - Review article
C2 - 16048718
AN - SCOPUS:22544448726
VL - 5
SP - 494
EP - 500
JO - The Lancet Infectious Diseases
JF - The Lancet Infectious Diseases
SN - 1473-3099
IS - 8
ER -