Intradermal pre-exposure rabies vaccine elicits long lasting immunity

David Brown; John J. Featherstone; Anthony R. Fooks; Sharmeen Gettner; Elizabeth Lloyd; Martin Schweiger

doi:10.1016/j.vaccine.2008.04.081

Intradermal pre-exposure rabies vaccine elicits long lasting immunity

David Brown, John J. Featherstone, Anthony R. Fooks, Sharmeen Gettner, Elizabeth Lloyd, Martin Schweiger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

A retrospective cohort study of current rabies antibody titres from adults who received pre-exposure immunisation administered intradermally between 1994 and 2005, examining the decay in titre over time relative to the interval since last dose, and the total dose received. Participants receiving at least 0.6 ml total dose intradermally of vaccine over at least two clinic visits and all with three clinic visits, were shown to have an adequate titre with measurable levels of antibody indicating sero-conversion above 0.5 IU/ml, irrespective of the time interval since the last dose. No clear relationship was found between time interval since immunisation and the level of antibody. Using a schedule that administers 0.6 ml of rabies vaccine over three clinic visits the boosting interval could be extended towards ten years; substantially cheaper than the standard licensed intramuscular dosing schedule.

Original language	English
Pages (from-to)	3909-3912
Number of pages	4
Journal	Vaccine
Volume	26
Issue number	31
DOIs	https://doi.org/10.1016/j.vaccine.2008.04.081
Publication status	Published - 23 Jul 2008

Bibliographical note

Funding Information:
Funding : ARF was funded by the UK Department for Environment, Food and Rural Affairs (Defra) by grant SEV3500.

Keywords

Immunisation
Immunity
Intradermal
Rabies

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2008.04.081

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title = "Intradermal pre-exposure rabies vaccine elicits long lasting immunity",

abstract = "A retrospective cohort study of current rabies antibody titres from adults who received pre-exposure immunisation administered intradermally between 1994 and 2005, examining the decay in titre over time relative to the interval since last dose, and the total dose received. Participants receiving at least 0.6 ml total dose intradermally of vaccine over at least two clinic visits and all with three clinic visits, were shown to have an adequate titre with measurable levels of antibody indicating sero-conversion above 0.5 IU/ml, irrespective of the time interval since the last dose. No clear relationship was found between time interval since immunisation and the level of antibody. Using a schedule that administers 0.6 ml of rabies vaccine over three clinic visits the boosting interval could be extended towards ten years; substantially cheaper than the standard licensed intramuscular dosing schedule.",

keywords = "Immunisation, Immunity, Intradermal, Rabies",

author = "David Brown and Featherstone, {John J.} and Fooks, {Anthony R.} and Sharmeen Gettner and Elizabeth Lloyd and Martin Schweiger",

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AU - Brown, David

AU - Featherstone, John J.

AU - Fooks, Anthony R.

AU - Gettner, Sharmeen

AU - Lloyd, Elizabeth

AU - Schweiger, Martin

N1 - Funding Information: Funding : ARF was funded by the UK Department for Environment, Food and Rural Affairs (Defra) by grant SEV3500.

PY - 2008/7/23

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AB - A retrospective cohort study of current rabies antibody titres from adults who received pre-exposure immunisation administered intradermally between 1994 and 2005, examining the decay in titre over time relative to the interval since last dose, and the total dose received. Participants receiving at least 0.6 ml total dose intradermally of vaccine over at least two clinic visits and all with three clinic visits, were shown to have an adequate titre with measurable levels of antibody indicating sero-conversion above 0.5 IU/ml, irrespective of the time interval since the last dose. No clear relationship was found between time interval since immunisation and the level of antibody. Using a schedule that administers 0.6 ml of rabies vaccine over three clinic visits the boosting interval could be extended towards ten years; substantially cheaper than the standard licensed intramuscular dosing schedule.

KW - Immunisation

KW - Immunity

KW - Intradermal

KW - Rabies

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JF - Vaccine

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ER -

Intradermal pre-exposure rabies vaccine elicits long lasting immunity

Abstract

Bibliographical note

Keywords

UN SDGs

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