International spread of an epidemic population of Salmonella enterica serotype Kentucky ST198 resistant to ciprofloxacin

Simon Le Hello, Rene S. Hendriksen, Benoît Doublet, Ian Fisher, Eva Møller Nielsen, Jean M. Whichard, Brahim Bouchrif, Kayode Fashae, Sophie A. Granier, Nathalie Jourdan-Da Silva, Axel Cloeckaert, E. John Threlfall, Frederick J. Angulo, Frank M. Aarestrup, John Wain, Francxois Xavier Weill*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    212 Citations (Scopus)

    Abstract

    National Salmonella surveillance systems from France, England and Wales, Denmark, and the United States identified the recent emergence of multidrug-resistant isolates of Salmonella enterica serotype Kentucky displaying high-level resistance to ciprofloxacin. A total of 489 human cases were identified during the period from 2002 (3 cases) to 2008 (174 cases). These isolates belonged to a single clone defined by the multilocus sequence type ST198, the XbaI-pulsed-field gel electrophoresis cluster X1, and the presence of the Salmonella genomic island 1 variant SGI1-K. This clone was probably selected in 3 steps in Egypt during the 1990s and the early 2000s and has now spread to several countries in Africa and, more recently, in the Middle East. Poultry has been identified as a potential major vehicle for infection by this clone. Continued surveillance and appropriate control measures should be implemented by national and international authorities to limit the spread of this strain.

    Original languageEnglish
    Pages (from-to)675-684
    Number of pages10
    JournalJournal of Infectious Diseases
    Volume204
    Issue number5
    DOIs
    Publication statusPublished - 1 Sept 2011

    Bibliographical note

    Funding Information:
    Permanent financial support came from the institutes, universities, or national agencies of the authors. The work conducted at the National Food Institute, Technical University of Denmark was supported by the World Health Organization Global Foodborne Infections Network (www.who.int/ gfn) and the Danish Research Agency (274-05-0117).

    Funding Information:
    The MLST data are publicly available at http://mlst.ucc.ie, which is currently funded by a grant from the Science Foundation of Ireland (05/ FE1/B882).

    Funding Information:
    This work was supported by the Institut Pasteur; the Danish Research Agency (274-05-0117); the World Health Organization Global Foodborne Infections Network; the Institut National de la Recherche Agronomique; the Health Protection Agency; the Statens Serum Institute; the Centers for Disease Control and Prevention; the Institut Pasteur du Maroc; the University of Ibadan; the Agence Franxcaise de Sécurité Sanitaire des Aliments; the Réseau international des Instituts Pasteur et instituts associés; and the Institut de Veille Sanitaire.

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