International Salmonella typhimurium DT104 infections, 1992-2001

Morten Helms*, Steen Ethelberg, Kåre Mølbak, Diane Lightfoot, J. Powling, Christian Berghold, Christian Kornshober, Ingrid Wybo, J. M. Collard, C. Godard, Dalia Dos Prazeres Rodrigues, Eliane Moura Falavina Dos Reis, Erica L. Fonseca, Kathryn Doré, James Flint, Frank Pollari, Rafiq Ahmed, Walter Demczuk, James Hospedales, Denise ClarkeMichelle Nurse-Lucas, Renata Karpiskova, Peter Gerner-Smidt, Noël Gill, Sarah O'Brien, John Threlfall, Anja Siitonen, Susanna Lukinmaa, Wolfgang Rabsch, Panayotis T. Tassios, Leonidas S. Tzouvelekis, Takis Panagiotopoulos, Judit Pàszti, Noelni Nógrády, Barbara Foley, Martin Cormican, Paul McKeown, Nahum Andorn, Ruti Yishai, Haruo Watanabe, Hidemasa Izumiya, Kwon Lee Bok, Shukho Kim, J. Selga, J. Jansone, Joel Mossong, François Schneider, Julie Haider, Paul Cuschieri, Wilfrid Van Pelt, Helen Heffernan, Carolyn Nicol, Karin Nygård, Trine Lise Stavnes, B. L. Cherkasskiy, Lynda Browning, John Coia, Karen Helena Keddy, Tersia Kruger, Miquel Anger Usera, Agneta Olsson, Patrick Boerlin, Timothy Barrett, Frederick J. Angulo, Jennifer E. Stevenson

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    210 Citations (Scopus)


    The incidence of multidrug-resistant (MDR) Salmonella Typhimurium infections in humans, and in particular MDR definitive phage type 104 (DT104), has increased substantially in many countries in the last 2 decades, often associated with increased illness. To examine the magnitude of this problem, a survey was conducted among countries with available antimicrobial resistance or phage typing surveillance data. A total of 29, primarily industrialized, countries participated in the survey, which covered the years 1992-2001. Overall, the incidence of MDR S. Typhimurium and DT104 increased continuously during this period, although the problem affected primarily Europe and North America. The increase appeared to have peaked in the United Kingdom but not in other countries. Also, the incidence of quinolone-resistant S. Typhimurium was increasing. This survey implies that MDR S. Typhimurium constitutes an increasing public health problem in large parts of the world and emphasizes the importance of surveillance and control programs.

    Original languageEnglish
    Pages (from-to)859-867
    Number of pages9
    JournalEmerging Infectious Diseases
    Issue number6
    Publication statusPublished - Jun 2005


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