International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology

Anna Nowak-Węgrzyn; Mirna Chehade; Marion E. Groetch; Jonathan M. Spergel; Robert A. Wood; Katrina Allen; Dan Atkins; Sami Bahna; Ashis V. Barad; Cecilia Berin; Terri Brown Whitehorn; A. Wesley Burks; Jean Christoph Caubet; Antonella Cianferoni; Marisa Conte; Carla Davis; Alessandro Fiocchi; Kate Grimshaw; Ruchi Gupta; Brittany Hofmeister; J. B. Hwang; Yitzhak Katz; George N. Konstantinou; Stephanie A. Leonard; Jennifer Lightdale; Sean McGhee; Sami Mehr; Stefano Miceli Sopo; Giovanno Monti; Antonella Muraro; Stacey Katherine Noel; Ichiro Nomura; Sally Noone; Hugh A. Sampson; Fallon Schultz; Scott H. Sicherer; Cecilia C. Thompson; Paul J. Turner; Carina Venter; A. Amity Westcott-Chavez; Matthew Greenhawt

doi:10.1016/j.jaci.2016.12.966

International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology

Anna Nowak-Węgrzyn^*, Mirna Chehade, Marion E. Groetch, Jonathan M. Spergel, Robert A. Wood, Katrina Allen, Dan Atkins, Sami Bahna, Ashis V. Barad, Cecilia Berin, Terri Brown Whitehorn, A. Wesley Burks, Jean Christoph Caubet, Antonella Cianferoni, Marisa Conte, Carla Davis, Alessandro Fiocchi, Kate Grimshaw, Ruchi Gupta, Brittany HofmeisterJ. B. Hwang, Yitzhak Katz, George N. Konstantinou, Stephanie A. Leonard, Jennifer Lightdale, Sean McGhee, Sami Mehr, Stefano Miceli Sopo, Giovanno Monti, Antonella Muraro, Stacey Katherine Noel, Ichiro Nomura, Sally Noone, Hugh A. Sampson, Fallon Schultz, Scott H. Sicherer, Cecilia C. Thompson, Paul J. Turner, Carina Venter, A. Amity Westcott-Chavez, Matthew Greenhawt

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

503 Citations (Scopus)

Abstract

Food protein–induced enterocolitis (FPIES) is a non-IgE cell- mediated food allergy that can be severe and lead to shock. Despite the potential seriousness of reactions, awareness of FPIES is low; high-quality studies providing insight into the pathophysiology, diagnosis, and management are lacking; and clinical outcomes are poorly established. This consensus document is the result of work done by an international workgroup convened through the Adverse Reactions to Foods Committee of the American Academy of Allergy, Asthma & Immunology and the International FPIES Association advocacy group. These are the first international evidence-based guidelines to improve the diagnosis and management of patients with FPIES. Research on prevalence, pathophysiology, diagnostic markers, and future treatments is necessary to improve the care of patients with FPIES. These guidelines will be updated periodically as more evidence becomes available.

Original language	English
Pages (from-to)	1111-1126.e4
Journal	Journal of Allergy and Clinical Immunology
Volume	139
Issue number	4
DOIs	https://doi.org/10.1016/j.jaci.2016.12.966
Publication status	Published - 1 Apr 2017

Bibliographical note

Publisher Copyright:
© 2017 The Authors

Keywords

Food protein–induced enterocolitis syndrome
guidelines
non–IgE-mediated food allergy

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Nowak-Węgrzyn, A., Chehade, M., Groetch, M. E., Spergel, J. M., Wood, R. A., Allen, K., Atkins, D., Bahna, S., Barad, A. V., Berin, C., Brown Whitehorn, T., Burks, A. W., Caubet, J. C., Cianferoni, A., Conte, M., Davis, C., Fiocchi, A., Grimshaw, K., Gupta, R., ... Greenhawt, M. (2017). International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology. Journal of Allergy and Clinical Immunology, 139(4), 1111-1126.e4. https://doi.org/10.1016/j.jaci.2016.12.966

Nowak-Węgrzyn, Anna ; Chehade, Mirna ; Groetch, Marion E. et al. / International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome : Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology. In: Journal of Allergy and Clinical Immunology. 2017 ; Vol. 139, No. 4. pp. 1111-1126.e4.

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title = "International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology",

abstract = "Food protein–induced enterocolitis (FPIES) is a non-IgE cell- mediated food allergy that can be severe and lead to shock. Despite the potential seriousness of reactions, awareness of FPIES is low; high-quality studies providing insight into the pathophysiology, diagnosis, and management are lacking; and clinical outcomes are poorly established. This consensus document is the result of work done by an international workgroup convened through the Adverse Reactions to Foods Committee of the American Academy of Allergy, Asthma & Immunology and the International FPIES Association advocacy group. These are the first international evidence-based guidelines to improve the diagnosis and management of patients with FPIES. Research on prevalence, pathophysiology, diagnostic markers, and future treatments is necessary to improve the care of patients with FPIES. These guidelines will be updated periodically as more evidence becomes available.",

keywords = "Food protein–induced enterocolitis syndrome, guidelines, non–IgE-mediated food allergy",

author = "Anna Nowak-W{\c e}grzyn and Mirna Chehade and Groetch, {Marion E.} and Spergel, {Jonathan M.} and Wood, {Robert A.} and Katrina Allen and Dan Atkins and Sami Bahna and Barad, {Ashis V.} and Cecilia Berin and {Brown Whitehorn}, Terri and Burks, {A. Wesley} and Caubet, {Jean Christoph} and Antonella Cianferoni and Marisa Conte and Carla Davis and Alessandro Fiocchi and Kate Grimshaw and Ruchi Gupta and Brittany Hofmeister and Hwang, {J. B.} and Yitzhak Katz and Konstantinou, {George N.} and Leonard, {Stephanie A.} and Jennifer Lightdale and Sean McGhee and Sami Mehr and Sopo, {Stefano Miceli} and Giovanno Monti and Antonella Muraro and Noel, {Stacey Katherine} and Ichiro Nomura and Sally Noone and Sampson, {Hugh A.} and Fallon Schultz and Sicherer, {Scott H.} and Thompson, {Cecilia C.} and Turner, {Paul J.} and Carina Venter and Westcott-Chavez, {A. Amity} and Matthew Greenhawt",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

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doi = "10.1016/j.jaci.2016.12.966",

language = "English",

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Nowak-Węgrzyn, A, Chehade, M, Groetch, ME, Spergel, JM, Wood, RA, Allen, K, Atkins, D, Bahna, S, Barad, AV, Berin, C, Brown Whitehorn, T, Burks, AW, Caubet, JC, Cianferoni, A, Conte, M, Davis, C, Fiocchi, A, Grimshaw, K, Gupta, R, Hofmeister, B, Hwang, JB, Katz, Y, Konstantinou, GN, Leonard, SA, Lightdale, J, McGhee, S, Mehr, S, Sopo, SM, Monti, G, Muraro, A, Noel, SK, Nomura, I, Noone, S, Sampson, HA, Schultz, F, Sicherer, SH, Thompson, CC, Turner, PJ, Venter, C, Westcott-Chavez, AA & Greenhawt, M 2017, 'International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology', Journal of Allergy and Clinical Immunology, vol. 139, no. 4, pp. 1111-1126.e4. https://doi.org/10.1016/j.jaci.2016.12.966

International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology. / Nowak-Węgrzyn, Anna; Chehade, Mirna; Groetch, Marion E. et al.
In: Journal of Allergy and Clinical Immunology, Vol. 139, No. 4, 01.04.2017, p. 1111-1126.e4.

Research output: Contribution to journal › Article › peer-review

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T1 - International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome

T2 - Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology

AU - Nowak-Węgrzyn, Anna

AU - Chehade, Mirna

AU - Groetch, Marion E.

AU - Spergel, Jonathan M.

AU - Wood, Robert A.

AU - Allen, Katrina

AU - Atkins, Dan

AU - Bahna, Sami

AU - Barad, Ashis V.

AU - Berin, Cecilia

AU - Brown Whitehorn, Terri

AU - Burks, A. Wesley

AU - Caubet, Jean Christoph

AU - Cianferoni, Antonella

AU - Conte, Marisa

AU - Davis, Carla

AU - Fiocchi, Alessandro

AU - Grimshaw, Kate

AU - Gupta, Ruchi

AU - Hofmeister, Brittany

AU - Hwang, J. B.

AU - Katz, Yitzhak

AU - Konstantinou, George N.

AU - Leonard, Stephanie A.

AU - Lightdale, Jennifer

AU - McGhee, Sean

AU - Mehr, Sami

AU - Sopo, Stefano Miceli

AU - Monti, Giovanno

AU - Muraro, Antonella

AU - Noel, Stacey Katherine

AU - Nomura, Ichiro

AU - Noone, Sally

AU - Sampson, Hugh A.

AU - Schultz, Fallon

AU - Sicherer, Scott H.

AU - Thompson, Cecilia C.

AU - Turner, Paul J.

AU - Venter, Carina

AU - Westcott-Chavez, A. Amity

AU - Greenhawt, Matthew

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AB - Food protein–induced enterocolitis (FPIES) is a non-IgE cell- mediated food allergy that can be severe and lead to shock. Despite the potential seriousness of reactions, awareness of FPIES is low; high-quality studies providing insight into the pathophysiology, diagnosis, and management are lacking; and clinical outcomes are poorly established. This consensus document is the result of work done by an international workgroup convened through the Adverse Reactions to Foods Committee of the American Academy of Allergy, Asthma & Immunology and the International FPIES Association advocacy group. These are the first international evidence-based guidelines to improve the diagnosis and management of patients with FPIES. Research on prevalence, pathophysiology, diagnostic markers, and future treatments is necessary to improve the care of patients with FPIES. These guidelines will be updated periodically as more evidence becomes available.

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Nowak-Węgrzyn A, Chehade M, Groetch ME, Spergel JM, Wood RA, Allen K et al. International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology. Journal of Allergy and Clinical Immunology. 2017 Apr 1;139(4):1111-1126.e4. doi: 10.1016/j.jaci.2016.12.966

International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology

Abstract

Bibliographical note

Keywords

Access to Document

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