Influenza vaccination for immunocompromised patients: Summary of a systematic review and meta-analysis

Charles Beck*, Bruce C. Mckenzie, Ahmed B. Hashim, Rebecca C. Harris, Arina Zanuzdana, Gabriel Agboado, Elizabeth Orton, Laura Béchard-Evans, Gemma Morgan, Charlotte Stevenson, Rachel Weston, Mitsuru Mukaigawara, Joanne Enstone, Glenda Augustine, Mobasher Butt, Sophie Kim, Richard Puleston, Girija Dabke, Robert Howard, Julie O'BoyleMary O'Brien, Lauren Ahyow, Helene Denness, Siobhan Farmer, Jose Figureroa, Paul Fisher, Felix Greaves, Munib Haroon, Sophie Haroon, Caroline Hird, Rachel Isba, David A. Ishola, Marko Kerac, Vivienne Parish, Jonathan Roberts, Julia Rosser, Sarah Theaker, Dean Wallace, Neil Wigglesworth, Liz Lingard, Yana Vinogradova, Hiroshi Horiuchi, Javier Peñalver, Jonathan S. Nguyen-Van-Tam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Vaccination of immunocompromised patients is recommended in many national guidelines to protect against severe or complicated influenza infection. However, due to uncertainties over the evidence base, implementation is frequently patchy and dependent on individual clinical discretion. We conducted a systematic review and meta-analysis to assess the evidence for influenza vaccination in this patient group. Healthcare databases and grey literature were searched and screened for eligibility. Data extraction and assessments of risk of bias were undertaken in duplicate, and results were synthesised narratively and using meta-analysis where possible. Our data show that whilst the serological response following vaccination of immunocompromised patients is less vigorous than in healthy controls, clinical protection is still meaningful, with only mild variation in adverse events between aetiological groups. Although we encountered significant clinical and statistical heterogeneity in many of our meta-analyses, we advocate that immunocompromised patients should be targeted for influenza vaccination.

Original languageEnglish
Pages (from-to)72-75
Number of pages4
JournalInfluenza and other Respiratory Viruses
Volume7
Issue numberSUPPL.2
DOIs
Publication statusPublished - 2013

Keywords

  • Immunocompromised
  • Influenza
  • Meta-analysis
  • Systematic review
  • Vaccination

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