Influenza interaction with cocirculating pathogens and its impact on surveillance, pathogenesis, and epidemic profile: A key role for mathematical modelling

Lulla Opatowski*, Marc Baguelin, Rosalind M. Eggo

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

51 Citations (Scopus)

Abstract

Evidence is mounting that influenza virus interacts with other pathogens colonising or infecting the human respiratory tract. Taking into account interactions with other pathogens may be critical to determining the real influenza burden and the full impact of public health policies targeting influenza. This is particularly true for mathematical modelling studies, which have become critical in public health decision-making. Yet models usually focus on influenza virus acquisition and infection alone, thereby making broad oversimplifications of pathogen ecology. Herein, we report evidence of influenza virus interactions with bacteria and viruses and systematically review the modelling studies that have incorporated interactions. Despite the many studies examining possible associations between influenza and Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Neisseria meningitidis, respiratory syncytial virus (RSV), human rhinoviruses, human parainfluenza viruses, etc., very few mathematical models have integrated other pathogens alongside influenza. The notable exception is the pneumococcus–influenza interaction, for which several recent modelling studies demonstrate the power of dynamic modelling as an approach to test biological hypotheses on interaction mechanisms and estimate the strength of those interactions. We explore how different interference mechanisms may lead to unexpected incidence trends and possible misinterpretation, and we illustrate the impact of interactions on public health surveillance using simple transmission models. We demonstrate that the development of multipathogen models is essential to assessing the true public health burden of influenza and that it is needed to help improve planning and evaluation of control measures. Finally, we identify the public health, surveillance, modelling, and biological challenges and propose avenues of research for the coming years.

Original languageEnglish
Article numbere1006770
JournalPLoS Pathogens
Volume14
Issue number2
DOIs
Publication statusPublished - Feb 2018

Bibliographical note

Funding Information:
Funding:LOacknowledgesfundingfromthe FrenchGovernment’s“Investissementd’Avenir” program,Laboratoired’Excellence“Integrative BiologyofEmergingInfectiousDiseases”(grant no. ANR-10-LABX-62-IBEID), and from Re ´ gion Île-de-France(Domained’Inte ´ rêtMajeurMaladies Infectieuses).RMEandMBacknowledgefunding fromtheNationalInstituteforHealthResearch throughtheHealthProtectionResearchUnitin ImmunisationattheLondonSchoolofHygiene& TropicalMedicineinpartnershipwithPublicHealth England.Thefundershadnoroleinstudydesign, datacollectionandanalysis,decisiontopublish,or preparationofthemanuscript.

Publisher Copyright:
© 2018 Opatowski et al.

Fingerprint

Dive into the research topics of 'Influenza interaction with cocirculating pathogens and its impact on surveillance, pathogenesis, and epidemic profile: A key role for mathematical modelling'. Together they form a unique fingerprint.

Cite this