Influence of Landscape Patterns on Exposure to Lassa Fever Virus, Guinea

Stephanie Longet; Cristina Leggio; Joseph Akoi Bore; Stephanie Key; Tom Tipton; Yper Hall; Fara Raymond Koundouno; Hilary Bower; Tapan Bhattacharyya; N'Faly Magassouba; Stephan Günther; Ana Maria Henao-Restrapo; Jeremy S. Rossman; Mandy Kader Konde; Kimberly Fornace; Miles W. Carroll

doi:10.3201/eid2902.212525

Influence of Landscape Patterns on Exposure to Lassa Fever Virus, Guinea

Stephanie Longet, Cristina Leggio, Joseph Akoi Bore, Stephanie Key, Tom Tipton, Yper Hall, Fara Raymond Koundouno, Hilary Bower, Tapan Bhattacharyya, N'Faly Magassouba, Stephan Günther, Ana Maria Henao-Restrapo, Jeremy S. Rossman, Mandy Kader Konde, Kimberly Fornace, Miles W. Carroll

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Lassa fever virus (LASV) is the causative agent of Lassa fever, a disease endemic in West Africa. Exploring the relationships between environmental factors and LASV transmission across ecologically diverse regions can provide crucial information for the design of appropriate interventions and disease monitoring. We investigated LASV exposure in 2 ecologically diverse regions of Guinea. Our results showed that exposure to LASV was heterogenous between and within sites. LASV IgG seropositivity was 11.9% (95% CI 9.7%–14.5%) in a coastal study site in Basse-Guinée, but it was 59.6% (95% CI 55.5%–63.5%) in a forested study site located in Guinée Forestière. Seropositivity increased with age in the coastal site. We also found significant associations between exposure risk for LASV and landscape fragmentation in coastal and forested regions. Our study highlights the potential link between environmental change and LASV emergence and the urgent need for research on land management practices that reduce disease risks.

Original language	English
Pages (from-to)	304-313
Number of pages	10
Journal	Emerging Infectious Diseases
Volume	29
Issue number	2
DOIs	https://doi.org/10.3201/eid2902.212525
Publication status	Published - Feb 2023

Bibliographical note

Funding Information:
This work was funded by the US Food and Drug Administration (grant no. HHSF223201510104C) and the CGIAR Research Program on Agriculture for Nutrition and Health (grant no. A4NH). S.G. was supported by grants from the German Research Foundation (grant nos. GU883/5-1 and GU883/5-2). K.F. is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (grant no. 221963/Z/20/Z).

Publisher Copyright:
© 2023 Centers for Disease Control and Prevention (CDC). All rights reserved.

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Longet, S., Leggio, C., Bore, J. A., Key, S., Tipton, T., Hall, Y., Koundouno, F. R., Bower, H., Bhattacharyya, T., Magassouba, NF., Günther, S., Henao-Restrapo, A. M., Rossman, J. S., Konde, M. K., Fornace, K., & Carroll, M. W. (2023). Influence of Landscape Patterns on Exposure to Lassa Fever Virus, Guinea. Emerging Infectious Diseases, 29(2), 304-313. https://doi.org/10.3201/eid2902.212525

@article{01ec8ba19dff4a88b6093a34b8dfe899,

title = "Influence of Landscape Patterns on Exposure to Lassa Fever Virus, Guinea",

abstract = "Lassa fever virus (LASV) is the causative agent of Lassa fever, a disease endemic in West Africa. Exploring the relationships between environmental factors and LASV transmission across ecologically diverse regions can provide crucial information for the design of appropriate interventions and disease monitoring. We investigated LASV exposure in 2 ecologically diverse regions of Guinea. Our results showed that exposure to LASV was heterogenous between and within sites. LASV IgG seropositivity was 11.9\% (95\% CI 9.7\%–14.5\%) in a coastal study site in Basse-Guin{\'e}e, but it was 59.6\% (95\% CI 55.5\%–63.5\%) in a forested study site located in Guin{\'e}e Foresti{\`e}re. Seropositivity increased with age in the coastal site. We also found significant associations between exposure risk for LASV and landscape fragmentation in coastal and forested regions. Our study highlights the potential link between environmental change and LASV emergence and the urgent need for research on land management practices that reduce disease risks.",

author = "Stephanie Longet and Cristina Leggio and Bore, \{Joseph Akoi\} and Stephanie Key and Tom Tipton and Yper Hall and Koundouno, \{Fara Raymond\} and Hilary Bower and Tapan Bhattacharyya and N'Faly Magassouba and Stephan G{\"u}nther and Henao-Restrapo, \{Ana Maria\} and Rossman, \{Jeremy S.\} and Konde, \{Mandy Kader\} and Kimberly Fornace and Carroll, \{Miles W.\}",

note = "Funding Information: This work was funded by the US Food and Drug Administration (grant no. HHSF223201510104C) and the CGIAR Research Program on Agriculture for Nutrition and Health (grant no. A4NH). S.G. was supported by grants from the German Research Foundation (grant nos. GU883/5-1 and GU883/5-2). K.F. is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (grant no. 221963/Z/20/Z). Publisher Copyright: {\textcopyright} 2023 Centers for Disease Control and Prevention (CDC). All rights reserved.",

year = "2023",

month = feb,

doi = "10.3201/eid2902.212525",

language = "English",

volume = "29",

pages = "304--313",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

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Longet, S, Leggio, C, Bore, JA, Key, S, Tipton, T, Hall, Y, Koundouno, FR, Bower, H, Bhattacharyya, T, Magassouba, NF, Günther, S, Henao-Restrapo, AM, Rossman, JS, Konde, MK, Fornace, K & Carroll, MW 2023, 'Influence of Landscape Patterns on Exposure to Lassa Fever Virus, Guinea', Emerging Infectious Diseases, vol. 29, no. 2, pp. 304-313. https://doi.org/10.3201/eid2902.212525

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T1 - Influence of Landscape Patterns on Exposure to Lassa Fever Virus, Guinea

AU - Longet, Stephanie

AU - Leggio, Cristina

AU - Bore, Joseph Akoi

AU - Key, Stephanie

AU - Tipton, Tom

AU - Hall, Yper

AU - Koundouno, Fara Raymond

AU - Bower, Hilary

AU - Bhattacharyya, Tapan

AU - Magassouba, N'Faly

AU - Günther, Stephan

AU - Henao-Restrapo, Ana Maria

AU - Rossman, Jeremy S.

AU - Konde, Mandy Kader

AU - Fornace, Kimberly

AU - Carroll, Miles W.

N1 - Funding Information: This work was funded by the US Food and Drug Administration (grant no. HHSF223201510104C) and the CGIAR Research Program on Agriculture for Nutrition and Health (grant no. A4NH). S.G. was supported by grants from the German Research Foundation (grant nos. GU883/5-1 and GU883/5-2). K.F. is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (grant no. 221963/Z/20/Z). Publisher Copyright: © 2023 Centers for Disease Control and Prevention (CDC). All rights reserved.

PY - 2023/2

Y1 - 2023/2

N2 - Lassa fever virus (LASV) is the causative agent of Lassa fever, a disease endemic in West Africa. Exploring the relationships between environmental factors and LASV transmission across ecologically diverse regions can provide crucial information for the design of appropriate interventions and disease monitoring. We investigated LASV exposure in 2 ecologically diverse regions of Guinea. Our results showed that exposure to LASV was heterogenous between and within sites. LASV IgG seropositivity was 11.9% (95% CI 9.7%–14.5%) in a coastal study site in Basse-Guinée, but it was 59.6% (95% CI 55.5%–63.5%) in a forested study site located in Guinée Forestière. Seropositivity increased with age in the coastal site. We also found significant associations between exposure risk for LASV and landscape fragmentation in coastal and forested regions. Our study highlights the potential link between environmental change and LASV emergence and the urgent need for research on land management practices that reduce disease risks.

AB - Lassa fever virus (LASV) is the causative agent of Lassa fever, a disease endemic in West Africa. Exploring the relationships between environmental factors and LASV transmission across ecologically diverse regions can provide crucial information for the design of appropriate interventions and disease monitoring. We investigated LASV exposure in 2 ecologically diverse regions of Guinea. Our results showed that exposure to LASV was heterogenous between and within sites. LASV IgG seropositivity was 11.9% (95% CI 9.7%–14.5%) in a coastal study site in Basse-Guinée, but it was 59.6% (95% CI 55.5%–63.5%) in a forested study site located in Guinée Forestière. Seropositivity increased with age in the coastal site. We also found significant associations between exposure risk for LASV and landscape fragmentation in coastal and forested regions. Our study highlights the potential link between environmental change and LASV emergence and the urgent need for research on land management practices that reduce disease risks.

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SN - 1080-6040

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JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

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ER -

Influence of Landscape Patterns on Exposure to Lassa Fever Virus, Guinea

Abstract

Bibliographical note

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