Influence of Chlamydia trachomatis Sequence Variation on pgp3 Antigenicity

Filomeno Coelho da Silva; Kazutomo Yokoya; Rana Hussain; Gathoni Kamuyu; Anna Godi; Marta Checchi; Tânia de Freitas Raso; Simon Beddows

doi:10.1093/infdis/jiag067

Influence of Chlamydia trachomatis Sequence Variation on pgp3 Antigenicity

Filomeno Coelho da Silva
, Kazutomo Yokoya
, Rana Hussain
, Gathoni Kamuyu
, Anna Godi
, Marta Checchi
, Tânia de Freitas Raso
, Simon Beddows^*

^*Corresponding author for this work

BBVU

Research output: Contribution to journal › Article › peer-review

Abstract

Chlamydia trachomatis (Ct) is a sexually transmitted infection (STI) linked to ectopic pregnancy, infertility, invasive lymphogranuloma venereum (LGV), and the blinding disease trachoma. STI, LGV, and trachoma are associated with disease-specific Ct genovars. Serology is an important surveillance tool for estimating exposure, but the impact of genome variation on the antigenicity of Ct proteins is unclear. Two-dimensional antigenicity profiling of Pgp3 antigens representing LGV, STI, and trachoma demonstrated differential antigenicity using antigen-specific murine sera, but geometric distances were not considered significant (≤2-fold) for human infection sera. Pgp3 should be considered a single serotype for the purposes of Ct serosurveillance.

Original language	English
Pages (from-to)	e1124-e1129
Journal	Journal of Infectious Diseases
Volume	233
Issue number	5
DOIs	https://doi.org/10.1093/infdis/jiag067
Publication status	Published - 4 Feb 2026

Bibliographical note

Publisher Copyright:
© Crown copyright 2026. This Open Access article contains public sector information licensed under the Open Government Licence v3.0 (https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chlamydia trachomatis
Pgp3
antibody
antigenicity
genovar

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10.1093/infdis/jiag067

Cite this

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title = "Influence of Chlamydia trachomatis Sequence Variation on pgp3 Antigenicity",

abstract = "Chlamydia trachomatis (Ct) is a sexually transmitted infection (STI) linked to ectopic pregnancy, infertility, invasive lymphogranuloma venereum (LGV), and the blinding disease trachoma. STI, LGV, and trachoma are associated with disease-specific Ct genovars. Serology is an important surveillance tool for estimating exposure, but the impact of genome variation on the antigenicity of Ct proteins is unclear. Two-dimensional antigenicity profiling of Pgp3 antigens representing LGV, STI, and trachoma demonstrated differential antigenicity using antigen-specific murine sera, but geometric distances were not considered significant (≤2-fold) for human infection sera. Pgp3 should be considered a single serotype for the purposes of Ct serosurveillance.",

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author = "\{da Silva\}, \{Filomeno Coelho\} and Kazutomo Yokoya and Rana Hussain and Gathoni Kamuyu and Anna Godi and Marta Checchi and \{de Freitas Raso\}, T{\^a}nia and Simon Beddows",

note = "Publisher Copyright: {\textcopyright} Crown copyright 2026. This Open Access article contains public sector information licensed under the Open Government Licence v3.0 (https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/).",

year = "2026",

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doi = "10.1093/infdis/jiag067",

language = "English",

volume = "233",

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T1 - Influence of Chlamydia trachomatis Sequence Variation on pgp3 Antigenicity

AU - da Silva, Filomeno Coelho

AU - Yokoya, Kazutomo

AU - Hussain, Rana

AU - Kamuyu, Gathoni

AU - Godi, Anna

AU - Checchi, Marta

AU - de Freitas Raso, Tânia

AU - Beddows, Simon

N1 - Publisher Copyright: © Crown copyright 2026. This Open Access article contains public sector information licensed under the Open Government Licence v3.0 (https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/).

PY - 2026/2/4

Y1 - 2026/2/4

N2 - Chlamydia trachomatis (Ct) is a sexually transmitted infection (STI) linked to ectopic pregnancy, infertility, invasive lymphogranuloma venereum (LGV), and the blinding disease trachoma. STI, LGV, and trachoma are associated with disease-specific Ct genovars. Serology is an important surveillance tool for estimating exposure, but the impact of genome variation on the antigenicity of Ct proteins is unclear. Two-dimensional antigenicity profiling of Pgp3 antigens representing LGV, STI, and trachoma demonstrated differential antigenicity using antigen-specific murine sera, but geometric distances were not considered significant (≤2-fold) for human infection sera. Pgp3 should be considered a single serotype for the purposes of Ct serosurveillance.

AB - Chlamydia trachomatis (Ct) is a sexually transmitted infection (STI) linked to ectopic pregnancy, infertility, invasive lymphogranuloma venereum (LGV), and the blinding disease trachoma. STI, LGV, and trachoma are associated with disease-specific Ct genovars. Serology is an important surveillance tool for estimating exposure, but the impact of genome variation on the antigenicity of Ct proteins is unclear. Two-dimensional antigenicity profiling of Pgp3 antigens representing LGV, STI, and trachoma demonstrated differential antigenicity using antigen-specific murine sera, but geometric distances were not considered significant (≤2-fold) for human infection sera. Pgp3 should be considered a single serotype for the purposes of Ct serosurveillance.

KW - Chlamydia trachomatis

KW - Pgp3

KW - antibody

KW - antigenicity

KW - genovar

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AN - SCOPUS:105039213723

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SP - e1124-e1129

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

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ER -

Influence of Chlamydia trachomatis Sequence Variation on pgp3 Antigenicity

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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