Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat

Osei B. Ansah; Nora Bourbia; Leonor Gonçalves; Armando Almeida; Antti Pertovaara

doi:10.1016/j.bbr.2010.01.021

Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat

Osei B. Ansah
, Nora Bourbia
, Leonor Gonçalves
, Armando Almeida
, Antti Pertovaara^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR₁ and mGluR₅, and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.

Original language	English
Pages (from-to)	174-178
Number of pages	5
Journal	Behavioural Brain Research
Volume	209
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2010.01.021
Publication status	Published - 1 May 2010
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported by the Academy of Finland , Helsinki, Finland, the Sigrid Jusélius Foundation , Helsinki, Finland, the Center for International Mobility (CIMO), Helsinki, Finland, the Portuguese Foundation for Science and Technology , Lisbon, Portugal, and the Gulbenkian Foundation , Lisbon, Portugal.

Keywords

Amygdala
Aversive place-conditioning
Descending pain modulation
Emotional pain
Mechanical pain sensibility
Peripheral neuropathy

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10.1016/j.bbr.2010.01.021

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title = "Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat",

abstract = "The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR1 and mGluR5, and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.",

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doi = "10.1016/j.bbr.2010.01.021",

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AU - Ansah, Osei B.

AU - Bourbia, Nora

AU - Gonçalves, Leonor

AU - Almeida, Armando

AU - Pertovaara, Antti

N1 - Funding Information: This study was supported by the Academy of Finland , Helsinki, Finland, the Sigrid Jusélius Foundation , Helsinki, Finland, the Center for International Mobility (CIMO), Helsinki, Finland, the Portuguese Foundation for Science and Technology , Lisbon, Portugal, and the Gulbenkian Foundation , Lisbon, Portugal.

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N2 - The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR1 and mGluR5, and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.

AB - The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR1 and mGluR5, and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.

KW - Amygdala

KW - Aversive place-conditioning

KW - Descending pain modulation

KW - Emotional pain

KW - Mechanical pain sensibility

KW - Peripheral neuropathy

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SN - 0166-4328

VL - 209

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EP - 178

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 1

ER -

Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat

Abstract

Bibliographical note

Keywords

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