Increasing burden of community-acquired pneumonia leading to hospitalisation, 1998-2014

behalf of the Infections in Oxfordshire Research Database (IORD)

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

Background Community-acquired pneumonia (CAP) is a major cause of mortality and morbidity in many countries but few recent large-scale studies have examined trends in its incidence. Methods Incidence of CAP leading to hospitalisation in one UK region (Oxfordshire) was calculated over calendar time using routinely collected diagnostic codes, and modelled using piecewise-linear Poisson regression. 1Further models considered other related diagnoses, typical administrative outcomes, and blood and microbiology test results at admission to determine whether CAP trends could be explained by changes in case-mix, coding practices or admission procedures. Results CAP increased by 4.2%/year (95% CI 3.6 to 4.8) from 1998 to 2008, and subsequently much faster at 8.8%/year (95% CI 7.8 to 9.7) from 2009 to 2014. Pneumonia-related conditions also increased significantly over this period. Length of stay and 30-day mortality decreased slightly in later years, but the proportions with abnormal neutrophils, urea and C reactive protein (CRP) did not change (p>0.2). The proportion with severely abnormal CRP (>100 mg/L) decreased slightly in later years. Trends were similar in all age groups. Streptococcus pneumoniae was the most common causative organism found; however other organisms, particularly Enterobacteriaceae, increased in incidence over the study period (p<0.001). Conclusions Hospitalisations for CAP have been increasing rapidly in Oxfordshire, particularly since 2008. There is little evidence that this is due only to changes in pneumonia coding, an ageing population or patients with substantially less severe disease being admitted more frequently. Healthcare planning to address potential further increases in admissions and consequent antibiotic prescribing should be a priority.

Original languageEnglish
Pages (from-to)535-542
Number of pages8
JournalThorax
Volume71
Issue number6
DOIs
Publication statusPublished - 1 Jun 2016

Bibliographical note

Funding Information:
This work was supported by the National Institute for Health Research Oxford Biomedical Research Centre and the Oxford NIHR Health Protection Research Unit (HPRU-2012-10041); a NIHR Research Methods Fellowship to TPQ (MET 11-27); and a Medical Research Council UK Clinical Research Training Fellowship to NJF (MR/M003736/1).

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Fingerprint

Dive into the research topics of 'Increasing burden of community-acquired pneumonia leading to hospitalisation, 1998-2014'. Together they form a unique fingerprint.

Cite this