Increased mortality in COVID-19 patients with fungal co- and secondary infections admitted to intensive care or high dependency units in NHS hospitals in England

Andrew M. Borman; Holly Fountain; Rebecca Guy; Ella Casale; Sarah M. Gerver; Suzanne Elgohari; Colin S. Brown; Susan Hopkins; Victoria J. Chalker; Elizabeth M. Johnson

doi:10.1016/j.jinf.2021.12.047

Increased mortality in COVID-19 patients with fungal co- and secondary infections admitted to intensive care or high dependency units in NHS hospitals in England

Andrew M. Borman^*
, Holly Fountain
, Rebecca Guy
, Ella Casale
, Sarah M. Gerver
, Suzanne Elgohari
, Colin S. Brown
, Susan Hopkins
, Victoria J. Chalker
, Elizabeth M. Johnson

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

7 Citations (Scopus)

Abstract

Highlights
• Patients with severe COVID-19 disease are at risk of fungal co/secondary infections.
• COVID-associated pulmonary aspergillosis and candidemia are most common.
• We estimate impact of fungal infections on outcome in COVID ICU patients in England.
• Aspergillosis and candidemia independently increase COVID-19-associated mortality.
• Length-of-stay was extended in COVID-19 patients with either fungal infection.

Original language	English
Pages (from-to)	579-613
Number of pages	35
Journal	Journal of Infection
Volume	84
Issue number	4
Early online date	4 Jan 2022
DOIs	https://doi.org/10.1016/j.jinf.2021.12.047
Publication status	Published - 8 Apr 2022

Keywords

CAPA
COVID-19
Fungal secondary infection
HDU
ICU
Length of stay
Mortality

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jinf.2021.12.047

Cite this

Borman, A. M., Fountain, H., Guy, R., Casale, E., Gerver, S. M., Elgohari, S., Brown, C. S., Hopkins, S., Chalker, V. J., & Johnson, E. M. (2022). Increased mortality in COVID-19 patients with fungal co- and secondary infections admitted to intensive care or high dependency units in NHS hospitals in England. Journal of Infection, 84(4), 579-613. https://doi.org/10.1016/j.jinf.2021.12.047

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title = "Increased mortality in COVID-19 patients with fungal co- and secondary infections admitted to intensive care or high dependency units in NHS hospitals in England",

abstract = "Highlights • Patients with severe COVID-19 disease are at risk of fungal co/secondary infections. • COVID-associated pulmonary aspergillosis and candidemia are most common. • We estimate impact of fungal infections on outcome in COVID ICU patients in England. • Aspergillosis and candidemia independently increase COVID-19-associated mortality. • Length-of-stay was extended in COVID-19 patients with either fungal infection.",

keywords = "CAPA, COVID-19, Fungal secondary infection, HDU, ICU, Length of stay, Mortality",

author = "Borman, \{Andrew M.\} and Holly Fountain and Rebecca Guy and Ella Casale and Gerver, \{Sarah M.\} and Suzanne Elgohari and Brown, \{Colin S.\} and Susan Hopkins and Chalker, \{Victoria J.\} and Johnson, \{Elizabeth M.\}",

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doi = "10.1016/j.jinf.2021.12.047",

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Borman, AM, Fountain, H, Guy, R, Casale, E, Gerver, SM, Elgohari, S , Brown, CS, Hopkins, S, Chalker, VJ & Johnson, EM 2022, 'Increased mortality in COVID-19 patients with fungal co- and secondary infections admitted to intensive care or high dependency units in NHS hospitals in England', Journal of Infection, vol. 84, no. 4, pp. 579-613. https://doi.org/10.1016/j.jinf.2021.12.047

TY - JOUR

T1 - Increased mortality in COVID-19 patients with fungal co- and secondary infections admitted to intensive care or high dependency units in NHS hospitals in England

AU - Borman, Andrew M.

AU - Fountain, Holly

AU - Guy, Rebecca

AU - Casale, Ella

AU - Gerver, Sarah M.

AU - Elgohari, Suzanne

AU - Brown, Colin S.

AU - Hopkins, Susan

AU - Chalker, Victoria J.

AU - Johnson, Elizabeth M.

PY - 2022/4/8

Y1 - 2022/4/8

N2 - Highlights • Patients with severe COVID-19 disease are at risk of fungal co/secondary infections. • COVID-associated pulmonary aspergillosis and candidemia are most common. • We estimate impact of fungal infections on outcome in COVID ICU patients in England. • Aspergillosis and candidemia independently increase COVID-19-associated mortality. • Length-of-stay was extended in COVID-19 patients with either fungal infection.

AB - Highlights • Patients with severe COVID-19 disease are at risk of fungal co/secondary infections. • COVID-associated pulmonary aspergillosis and candidemia are most common. • We estimate impact of fungal infections on outcome in COVID ICU patients in England. • Aspergillosis and candidemia independently increase COVID-19-associated mortality. • Length-of-stay was extended in COVID-19 patients with either fungal infection.

KW - CAPA

KW - COVID-19

KW - Fungal secondary infection

KW - HDU

KW - ICU

KW - Length of stay

KW - Mortality

UR - https://www.scopus.com/pages/publications/85127776171

U2 - 10.1016/j.jinf.2021.12.047

DO - 10.1016/j.jinf.2021.12.047

M3 - Letter

C2 - 34995636

AN - SCOPUS:85127776171

SN - 0163-4453

VL - 84

SP - 579

EP - 613

JO - Journal of Infection

JF - Journal of Infection

IS - 4

ER -

Increased mortality in COVID-19 patients with fungal co- and secondary infections admitted to intensive care or high dependency units in NHS hospitals in England

Abstract

Keywords

UN SDGs

Access to Document

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