Increased mortality in COVID-19 patients with fungal co- and secondary infections admitted to intensive care or high dependency units in NHS hospitals in England

Andrew M. Borman; Holly Fountain; Rebecca Guy; Ella Casale; Sarah M. Gerver; Suzanne Elgohari; Colin S. Brown; Susan Hopkins; Victoria J. Chalker; Elizabeth M. Johnson

doi:10.1016/j.jinf.2021.12.047

Increased mortality in COVID-19 patients with fungal co- and secondary infections admitted to intensive care or high dependency units in NHS hospitals in England

Andrew M. Borman^*, Holly Fountain, Rebecca Guy, Ella Casale, Sarah M. Gerver, Suzanne Elgohari, Colin S. Brown, Susan Hopkins, Victoria J. Chalker, Elizabeth M. Johnson

^*Corresponding author for this work

UK Health Security Agency

Research output: Contribution to journal › Letter › peer-review

6 Citations (Scopus)

Abstract

Highlights
• Patients with severe COVID-19 disease are at risk of fungal co/secondary infections.
• COVID-associated pulmonary aspergillosis and candidemia are most common.
• We estimate impact of fungal infections on outcome in COVID ICU patients in England.
• Aspergillosis and candidemia independently increase COVID-19-associated mortality.
• Length-of-stay was extended in COVID-19 patients with either fungal infection.

Original language	English
Pages (from-to)	579-613
Number of pages	35
Journal	Journal of Infection
Volume	84
Issue number	4
Early online date	4 Jan 2022
DOIs	https://doi.org/10.1016/j.jinf.2021.12.047
Publication status	Published - 8 Apr 2022

Keywords

CAPA
COVID-19
Fungal secondary infection
HDU
ICU
Length of stay
Mortality

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jinf.2021.12.047

Cite this

Borman, A. M., Fountain, H., Guy, R., Casale, E., Gerver, S. M., Elgohari, S., Brown, C. S., Hopkins, S., Chalker, V. J., & Johnson, E. M. (2022). Increased mortality in COVID-19 patients with fungal co- and secondary infections admitted to intensive care or high dependency units in NHS hospitals in England. Journal of Infection, 84(4), 579-613. https://doi.org/10.1016/j.jinf.2021.12.047

@article{5792031508cd418ea8c6332e03e2f3d9,

title = "Increased mortality in COVID-19 patients with fungal co- and secondary infections admitted to intensive care or high dependency units in NHS hospitals in England",

abstract = "Highlights• Patients with severe COVID-19 disease are at risk of fungal co/secondary infections.• COVID-associated pulmonary aspergillosis and candidemia are most common.• We estimate impact of fungal infections on outcome in COVID ICU patients in England.• Aspergillosis and candidemia independently increase COVID-19-associated mortality.• Length-of-stay was extended in COVID-19 patients with either fungal infection.",

keywords = "CAPA, COVID-19, Fungal secondary infection, HDU, ICU, Length of stay, Mortality",

author = "Borman, {Andrew M.} and Holly Fountain and Rebecca Guy and Ella Casale and Gerver, {Sarah M.} and Suzanne Elgohari and Brown, {Colin S.} and Susan Hopkins and Chalker, {Victoria J.} and Johnson, {Elizabeth M.}",

year = "2022",

month = apr,

day = "8",

doi = "10.1016/j.jinf.2021.12.047",

language = "English",

volume = "84",

pages = "579--613",

journal = "Journal of Infection",

issn = "0163-4453",

publisher = "W.B. Saunders Ltd",

number = "4",

}

Borman, AM, Fountain, H, Guy, R, Casale, E, Gerver, SM, Elgohari, S , Brown, CS , Hopkins, S, Chalker, VJ & Johnson, EM 2022, 'Increased mortality in COVID-19 patients with fungal co- and secondary infections admitted to intensive care or high dependency units in NHS hospitals in England', Journal of Infection, vol. 84, no. 4, pp. 579-613. https://doi.org/10.1016/j.jinf.2021.12.047

TY - JOUR

T1 - Increased mortality in COVID-19 patients with fungal co- and secondary infections admitted to intensive care or high dependency units in NHS hospitals in England

AU - Borman, Andrew M.

AU - Fountain, Holly

AU - Guy, Rebecca

AU - Casale, Ella

AU - Gerver, Sarah M.

AU - Elgohari, Suzanne

AU - Brown, Colin S.

AU - Hopkins, Susan

AU - Chalker, Victoria J.

AU - Johnson, Elizabeth M.

PY - 2022/4/8

Y1 - 2022/4/8

N2 - Highlights• Patients with severe COVID-19 disease are at risk of fungal co/secondary infections.• COVID-associated pulmonary aspergillosis and candidemia are most common.• We estimate impact of fungal infections on outcome in COVID ICU patients in England.• Aspergillosis and candidemia independently increase COVID-19-associated mortality.• Length-of-stay was extended in COVID-19 patients with either fungal infection.

AB - Highlights• Patients with severe COVID-19 disease are at risk of fungal co/secondary infections.• COVID-associated pulmonary aspergillosis and candidemia are most common.• We estimate impact of fungal infections on outcome in COVID ICU patients in England.• Aspergillosis and candidemia independently increase COVID-19-associated mortality.• Length-of-stay was extended in COVID-19 patients with either fungal infection.

KW - CAPA

KW - COVID-19

KW - Fungal secondary infection

KW - HDU

KW - ICU

KW - Length of stay

KW - Mortality

UR - http://www.scopus.com/inward/record.url?scp=85127776171&partnerID=8YFLogxK

U2 - 10.1016/j.jinf.2021.12.047

DO - 10.1016/j.jinf.2021.12.047

M3 - Letter

C2 - 34995636

AN - SCOPUS:85127776171

SN - 0163-4453

VL - 84

SP - 579

EP - 613

JO - Journal of Infection

JF - Journal of Infection

IS - 4

ER -

Increased mortality in COVID-19 patients with fungal co- and secondary infections admitted to intensive care or high dependency units in NHS hospitals in England

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this