Incidence of childhood renal tumours: An international population-based study

IICC-3 contributors

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    Abstract

    Malignant renal tumours represent 5% of childhood cancers and include types with likely different aetiology: Wilms tumour (WT), rhabdoid renal tumour, kidney sarcomas and renal carcinomas. WT is the most common renal tumour in children, previously shown to vary internationally and with ethnicity. Using the comprehensive database of the International Incidence of Childhood Cancer study (IICC), we analysed global variations and time trends in incidence of renal tumour types in children (age 0-14 years) and adolescents (age 15-19 years). The results were presented by 14 world regions, and five ethnic groups in the US. We included 15 320 renal tumours in children and 800 in adolescents reported to the 163 contributing registries during 2001-2010. In children, age-standardised incidence rate (ASR) of renal tumours was 8.3 per million (95% confidence interval, CI = 8.1, 8.4); it was the highest in North America and Europe (9-10 per million) and the lowest in most Asian regions (4-5 per million). In the US, Blacks had the highest ASR (10.9 per million, 95% CI = 10.2, 11.6) and Asian and Pacific Islanders the lowest (4.4 per million, 95% CI = 3.6, 5.1). In adolescents, age-specific incidence rate of renal tumours was 1.4 per million (95% CI = 1.3, 1.5). WT accounted for over 90% of all renal tumours in each age from 1 to 7 years and the proportion of renal carcinomas increased gradually with age. From 1996 to 2010, incidence remained mostly stable for WT (average annual percent change, AAPC = 0.1) and increased for renal carcinomas in children (AAPC = 3.7) and adolescents (AAPC = 3.2). Our findings warrant further monitoring.

    Original languageEnglish
    Pages (from-to)3313-3327
    Number of pages15
    JournalInternational Journal of Cancer
    Volume147
    Issue number12
    Early online date16 Jun 2020
    DOIs
    Publication statusPublished - 15 Dec 2020

    Bibliographical note

    Funding Information: IICC‐3 has been supported by the IARC and by the Union for International Cancer Control (UICC). Study of renal tumors has been supported by a UICC Technical Fellowship [UICC‐TF/18/534491] awarded to K.N. Publication charges were supported by Grant‐in‐aid for Cancer Control Policy from the Ministry of Health, Labour and Welfare, Japan [20EA1026]. K.P.J. is supported in part by the National Institutes of Health Research (NIHR) Great Ormond Street Hospital Biomedical Research Centre. Our study is a result of coordinated effort of all data providers, dedicated work of the staff in the named registries and the registries funders specified in the IICC‐3 publication, which we all gratefully acknowledge.

    Open Access: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

    Publisher Copyright: © 2020 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of Union for International Cancer Control.

    Citation: : Nakata K, Colombet M, Stiller CA, Pritchard-Jones K, Steliarova-Foucher E, IICC-3 Contributors. Incidence of childhood renal tumours: An international population-based study. Int. J. Cancer. 2020;147:3313–3327.

    DOI: https://doi.org/10.1002/ijc.33147

    Keywords

    • Wilms tumour
    • cancer epidemiology
    • childhood renal tumour
    • paediatric kidney cancer
    • population-based cancer registry study

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