TY - JOUR
T1 - In-vitro photobactericidal activity of aminoacridines
AU - Wainwright, M.
AU - Phoenix, D. A.
AU - Marland, J.
AU - Wareing, D. R.A.
AU - Bolton, F. J.
PY - 1997/10
Y1 - 1997/10
N2 - The toxicities of several aminoacridines were measured against pathogenic strains of both Gram-positive (Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) organisms. In several cases, illumination at a light dose of 6.3 J/cm2 resulted in considerable decreases in the minimum lethal drug concentrations required, giving up to 50-fold increases in bactericidal activity. Derivatives of 9-aminoacridine (aminacrine) exhibited phototoxicity against one or more of the test organisms, but the established photosensitizing acridines proflavine and acridine orange were photobactericidal against all strains.
AB - The toxicities of several aminoacridines were measured against pathogenic strains of both Gram-positive (Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) organisms. In several cases, illumination at a light dose of 6.3 J/cm2 resulted in considerable decreases in the minimum lethal drug concentrations required, giving up to 50-fold increases in bactericidal activity. Derivatives of 9-aminoacridine (aminacrine) exhibited phototoxicity against one or more of the test organisms, but the established photosensitizing acridines proflavine and acridine orange were photobactericidal against all strains.
UR - http://www.scopus.com/inward/record.url?scp=0030723958&partnerID=8YFLogxK
U2 - 10.1093/jac/40.4.587
DO - 10.1093/jac/40.4.587
M3 - Article
C2 - 9372431
AN - SCOPUS:0030723958
SN - 0305-7453
VL - 40
SP - 587
EP - 589
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - 4
ER -
