In vitro-clinical correlations for amphotericin B susceptibility in AIDS-associated cryptococcal meningitis

R. A. Larsen*, M. Bauer, A. E. Brouwer, A. Sanchez, A. M. Thomas, A. Rajanuwong, W. Chierakul, S. J. Peacock, N. Day, N. J. White, M. G. Rinaldi, T. S. Harrison

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Reliable measures of antifungal drug susceptibility are needed. We tested the susceptibility of Cryptococcus neoformans from patients treated with amphotericin B. In vitro susceptibility employed a modified broth macrodilution method. We demonstrate a strong correlation between the quantitative measures of in vitro amphotericin B susceptibility and the quantitative response observed in patients.

Original languageEnglish
Pages (from-to)343-345
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number1
DOIs
Publication statusPublished - Jan 2007
Externally publishedYes

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