TY - JOUR
T1 - In vitro assessment of rokitamycin against problem gram-positive cocci
AU - Hamilton-Miller, J. M.T.
AU - Maple, P. A.C.
PY - 1992
Y1 - 1992
N2 - Rokitamycin was more active than erythromycin against erythromycin-sensitive strains of Staphylococcus aureus and enterococci, but somewhat less active against coagulase-negative staphylococci. Strains with inducible resistance to erythromycin were uniformly resistant to erythromycin, while rokitamycin was active against such strains. Strains with constitutive resistance to erythromycin were also uniformly resistant to erythromycin, and most were also resistant to rokitamycin. However, 5 of 21 coagulase-negative staphylococci and 2 of 20 enterococci remained sensitive to rokitamycin. This is a novel finding, perhaps suggesting a new mechanism of macrolide resistance.
AB - Rokitamycin was more active than erythromycin against erythromycin-sensitive strains of Staphylococcus aureus and enterococci, but somewhat less active against coagulase-negative staphylococci. Strains with inducible resistance to erythromycin were uniformly resistant to erythromycin, while rokitamycin was active against such strains. Strains with constitutive resistance to erythromycin were also uniformly resistant to erythromycin, and most were also resistant to rokitamycin. However, 5 of 21 coagulase-negative staphylococci and 2 of 20 enterococci remained sensitive to rokitamycin. This is a novel finding, perhaps suggesting a new mechanism of macrolide resistance.
UR - https://www.scopus.com/pages/publications/0026514765
U2 - 10.1080/1120009X.1992.11739129
DO - 10.1080/1120009X.1992.11739129
M3 - Article
C2 - 1403073
AN - SCOPUS:0026514765
SN - 1120-009X
VL - 4
SP - 6
EP - 8
JO - Journal of Chemotherapy
JF - Journal of Chemotherapy
IS - 1
ER -
