Improved hepatitis C treatment response in younger patients: Findings from the UK HCV National Register cohort study

Helen Harris*, A. Costella, Gayatri Amirthalingam, G. Alexander, Mary Ramsay, Nicholas Andrews

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    In a cohort of 272 treatment-naive individuals with chronic hepatitis C infection acquired on a known date who were enrolled in the UK HCV National Register, a progressive improvement in response to treatment was found with the evolution of antiviral therapies from 20% (25/122) for interferon monotherapy to 63% (55/88) for pegylated interferon+ribavirin therapy. Multivariable analysis results showed increasing age to be associated with poorer response to therapy [odds ratio (OR) 0 84, 95% confidence interval (CI) 0 72-0 99, P=0 03] whereas time since infection was not associated with response (OR 0 93, 95% CI 0 44-1 98, P=0 85). Other factors significantly associated with a positive response were non-type 1 genotype (P<0 0001) and combination therapies (P<0 0001). During the first two decades of chronic HCV infection, treatment at a younger age was found to be more influential in achieving a sustained viral response than treating earlier in the course of infection.

    Original languageEnglish
    Pages (from-to)1830-1837
    Number of pages8
    JournalEpidemiology and Infection
    Volume140
    Issue number10
    DOIs
    Publication statusPublished - Oct 2012

    Keywords

    • Age at treatment
    • HCV
    • hepatitis C
    • treatment

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