TY - JOUR
T1 - Improved hepatitis C treatment response in younger patients
T2 - Findings from the UK HCV National Register cohort study
AU - Harris, Helen
AU - Costella, A.
AU - Amirthalingam, Gayatri
AU - Alexander, G.
AU - Ramsay, Mary
AU - Andrews, Nicholas
PY - 2012/10
Y1 - 2012/10
N2 - In a cohort of 272 treatment-naive individuals with chronic hepatitis C infection acquired on a known date who were enrolled in the UK HCV National Register, a progressive improvement in response to treatment was found with the evolution of antiviral therapies from 20% (25/122) for interferon monotherapy to 63% (55/88) for pegylated interferon+ribavirin therapy. Multivariable analysis results showed increasing age to be associated with poorer response to therapy [odds ratio (OR) 0 84, 95% confidence interval (CI) 0 72-0 99, P=0 03] whereas time since infection was not associated with response (OR 0 93, 95% CI 0 44-1 98, P=0 85). Other factors significantly associated with a positive response were non-type 1 genotype (P<0 0001) and combination therapies (P<0 0001). During the first two decades of chronic HCV infection, treatment at a younger age was found to be more influential in achieving a sustained viral response than treating earlier in the course of infection.
AB - In a cohort of 272 treatment-naive individuals with chronic hepatitis C infection acquired on a known date who were enrolled in the UK HCV National Register, a progressive improvement in response to treatment was found with the evolution of antiviral therapies from 20% (25/122) for interferon monotherapy to 63% (55/88) for pegylated interferon+ribavirin therapy. Multivariable analysis results showed increasing age to be associated with poorer response to therapy [odds ratio (OR) 0 84, 95% confidence interval (CI) 0 72-0 99, P=0 03] whereas time since infection was not associated with response (OR 0 93, 95% CI 0 44-1 98, P=0 85). Other factors significantly associated with a positive response were non-type 1 genotype (P<0 0001) and combination therapies (P<0 0001). During the first two decades of chronic HCV infection, treatment at a younger age was found to be more influential in achieving a sustained viral response than treating earlier in the course of infection.
KW - Age at treatment
KW - HCV
KW - hepatitis C
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=84865520396&partnerID=8YFLogxK
U2 - 10.1017/S0950268811002317
DO - 10.1017/S0950268811002317
M3 - Article
C2 - 22124380
AN - SCOPUS:84865520396
VL - 140
SP - 1830
EP - 1837
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
IS - 10
ER -
