Impact of the 7-valent pneumococcal conjugate vaccine on the incidence of childhood pneumonia

M. A. Elemraid*, S. P. Rushton, M. D.F. Shirley, M. F. Thomas, D. A. Spencer, K. M. Eastham, F. Hampton, Russell Gorton, K. Pollard, A. R. Gennery, J. E. Clark

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    28 Citations (Scopus)

    Abstract

    In September 2006, the 7-valent pneumococcal conjugate vaccine (PCV7) was added to the UK immunization programme. We aimed to evaluate the impact of PCV7 on the incidence of all-cause community-acquired pneumonia (CAP) in children. A prospective survey was undertaken in 2008-2009 at 11 hospitals in North East England of children aged 0-16 years with radiologically confirmed pneumonia. Data were compared to those from a similar survey undertaken in the same hospitals in 2001-2002. A total of 542 children were enrolled, of which 74% were aged <5 years. PCV7 uptake was 90·7%. The incidence of pneumonia was 11·8/10 000 [95% confidence interval (CI) 10·9-12·9], and the hospitalization rate was 9·9/10 000 (95% CI 9·0-10·9). Compared to 2001, there was a 19% (95% CI 8-29) reduction in the rate of CAP in those aged <5 years, and in those <2 years a 33·1% (95% CI 20-45) reduction in the incidence of CAP and 38·1% (95% CI 24-50) reduction in hospitalization rates. However, for those unvaccinated aged ≥5 years, there was no difference in the incidence of CAP and hospitalization rate between both surveys. Since 2001, the overall reduction in incidence was 17·7% (95% CI 8-26) and for hospitalization 18·5% (95% CI 8-28). For the <5 years age group there was a lower incidence of CAP in PCV7-vaccinated children (25·2/10 000, 95% CI 22·6-28·2) than in those that were not vaccinated (37·4/10 000, 95% CI 29·2-47·1). In conclusion, PCV7 has reduced both incidence and rate of hospitalization of pneumonia in children, particularly in the <2 years age group.

    Original languageEnglish
    Pages (from-to)1697-1704
    Number of pages8
    JournalEpidemiology and Infection
    Volume141
    Issue number8
    DOIs
    Publication statusPublished - Aug 2013

    Keywords

    • Children
    • incidence
    • pneumococcal conjugate vaccine
    • pneumonia

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