TY - JOUR
T1 - Impact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole
T2 - An exploratory analysis from a randomized controlled clinical trial
AU - Guerrero, Adrián
AU - Nibali, Luigi
AU - Lambertenghi, Roberta
AU - Ready, Derren
AU - Suvan, Jean
AU - Griffiths, Gareth S.
AU - Wilson, Michael
AU - Tonetti, Maurizio S.
N1 - Publisher Copyright:
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2014
Y1 - 2014
N2 - Aim: To explore whether subjects harbouring A. actinomycetemcomitans, P. gingivalis or T. forsythia at baseline showed increased clinical benefits with the adjunctive use of systemic amoxicillin and metronidazole (AMX-MET) during non-surgical treatment of generalized aggressive periodontitis (GAgP). Material and Methods: Forty one subjects were included in this 6-month randomized placebo-controlled clinical trial using a 7-day course of systemic AMX-MET or placebo as adjuncts to non-surgical periodontal therapy. Clinical and microbiological parameters were collected at baseline, 2 and 6 months after treatment. Microbiological cultures were processed for pooled subgingival samples and identities of isolates were determined by PCR for A. actinomycetemcomitans, P. gingivalis and T. forsythia Results: At 6 months, the test treatment resulted in significant additional improvements in the primary outcome variable compared to placebo, and the effect of the adjunctive antimicrobials was not modified by the baseline microbiological status in the primary analysis.
AB - Aim: To explore whether subjects harbouring A. actinomycetemcomitans, P. gingivalis or T. forsythia at baseline showed increased clinical benefits with the adjunctive use of systemic amoxicillin and metronidazole (AMX-MET) during non-surgical treatment of generalized aggressive periodontitis (GAgP). Material and Methods: Forty one subjects were included in this 6-month randomized placebo-controlled clinical trial using a 7-day course of systemic AMX-MET or placebo as adjuncts to non-surgical periodontal therapy. Clinical and microbiological parameters were collected at baseline, 2 and 6 months after treatment. Microbiological cultures were processed for pooled subgingival samples and identities of isolates were determined by PCR for A. actinomycetemcomitans, P. gingivalis and T. forsythia Results: At 6 months, the test treatment resulted in significant additional improvements in the primary outcome variable compared to placebo, and the effect of the adjunctive antimicrobials was not modified by the baseline microbiological status in the primary analysis.
KW - Aggregatibacter actinomycetemcomitans
KW - Antimicrobials
KW - Exploratory analysis
KW - Generalized aggressive periodontitis
KW - Human
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=84964253493&partnerID=8YFLogxK
U2 - 10.1111/jcpe.12299
DO - 10.1111/jcpe.12299
M3 - Article
C2 - 25139116
AN - SCOPUS:84964253493
SN - 0303-6979
VL - 41
SP - 1080
EP - 1089
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
IS - 11
ER -