Immunomodulation using bacterial enterotoxins

C. P. Simmons; M. Ghaem-Magami; L. Petrovska; L. Lopes; B. M. Chain; N. A. Williams; G. Dougan

doi:10.1046/j.1365-3083.2001.00884.x

Immunomodulation using bacterial enterotoxins

C. P. Simmons^*
, M. Ghaem-Magami
, L. Petrovska
, L. Lopes
, B. M. Chain
, N. A. Williams
, G. Dougan

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

60 Citations (Scopus)

Abstract

Immunologic unresponsiveness (tolerance) is a key feature of the mucosal immune system, and deliberate vaccination by a mucosal route can effectively induce immune suppression. However, some bacterial-derived proteins, e.g. cholera toxin and the heat labile toxin of Escherichia coli, are immunogenic and immunomodulatory at mucosal surfaces and can effectively adjuvant immune responses to codelivered bystander antigens. This review summarizes some of the structural and biological characteristics of these toxins and provides examples of how these properties have been exploited for tolerance induction and mucosal vaccine development.

Original language	English
Pages (from-to)	218-226
Number of pages	9
Journal	Scandinavian Journal of Immunology
Volume	53
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-3083.2001.00884.x
Publication status	Published - 2001
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1046/j.1365-3083.2001.00884.x

Cite this

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title = "Immunomodulation using bacterial enterotoxins",

abstract = "Immunologic unresponsiveness (tolerance) is a key feature of the mucosal immune system, and deliberate vaccination by a mucosal route can effectively induce immune suppression. However, some bacterial-derived proteins, e.g. cholera toxin and the heat labile toxin of Escherichia coli, are immunogenic and immunomodulatory at mucosal surfaces and can effectively adjuvant immune responses to codelivered bystander antigens. This review summarizes some of the structural and biological characteristics of these toxins and provides examples of how these properties have been exploited for tolerance induction and mucosal vaccine development.",

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AU - Simmons, C. P.

AU - Ghaem-Magami, M.

AU - Petrovska, L.

AU - Lopes, L.

AU - Chain, B. M.

AU - Williams, N. A.

AU - Dougan, G.

PY - 2001

Y1 - 2001

N2 - Immunologic unresponsiveness (tolerance) is a key feature of the mucosal immune system, and deliberate vaccination by a mucosal route can effectively induce immune suppression. However, some bacterial-derived proteins, e.g. cholera toxin and the heat labile toxin of Escherichia coli, are immunogenic and immunomodulatory at mucosal surfaces and can effectively adjuvant immune responses to codelivered bystander antigens. This review summarizes some of the structural and biological characteristics of these toxins and provides examples of how these properties have been exploited for tolerance induction and mucosal vaccine development.

AB - Immunologic unresponsiveness (tolerance) is a key feature of the mucosal immune system, and deliberate vaccination by a mucosal route can effectively induce immune suppression. However, some bacterial-derived proteins, e.g. cholera toxin and the heat labile toxin of Escherichia coli, are immunogenic and immunomodulatory at mucosal surfaces and can effectively adjuvant immune responses to codelivered bystander antigens. This review summarizes some of the structural and biological characteristics of these toxins and provides examples of how these properties have been exploited for tolerance induction and mucosal vaccine development.

UR - https://www.scopus.com/pages/publications/0035127485

U2 - 10.1046/j.1365-3083.2001.00884.x

DO - 10.1046/j.1365-3083.2001.00884.x

M3 - Review article

C2 - 11251877

AN - SCOPUS:0035127485

SN - 0300-9475

VL - 53

SP - 218

EP - 226

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

IS - 3

ER -

Immunomodulation using bacterial enterotoxins

Abstract

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