Immunogenicity of a reduced schedule of pneumococcal conjugate vaccine in healthy infants and correlates of protection for serotype 6B in the united kingdom

David Goldblatt*, Joanna Southern, Lindsey Ashton, Nicholas Andrews, Sarah Woodgate, Polly Burbidge, Pauline Waight, Elizbeth Miller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

BACKGROUND: Pneumococcal conjugate vaccine (PCV) was introduced in the United Kingdom immunization schedule in September 2006. This study was conducted to establish the immunogenicity of licensed PCV (Prevenar) at a reduced, 2 priming dose schedule (2+1) and to evaluate functional responses in the context of vaccine effectiveness. METHODS: Infants were randomized to receive PCV at 2 and 3 months or 2 and 4 months of age. Boosters were administered at the same time as Haemophilus influenzae type B/meningococcal C conjugate and Measles, Mumps and Rubella or with Measles, Mumps and Rubella alone (www.ClinicalTrials. gov NCT00197808). RESULTS: PCV at 2/3 months of age was poorly immunogenic and recruitment to this arm was terminated. PCV at 2/4 months of age resulted in lower than expected responses to serotypes 6B and 23F. Functional analysis of serotype 6B by OPA revealed that an enzyme-linked immunosorbent assay cutoff of 0.2 μg/mL was a better predictor of OPA positivity than a cut off of 0.35 μg/mL. PCV booster responses were excellent and no interference from concomitant vaccines was noted. CONCLUSIONS: An interval of at least 8 weeks is required when starting PCV vaccination at 2 months of age although not all serotypes are equally immunogenic. Correlates of protection derived from enzyme-linked immunosorbent assay values may not be equally appropriate for all serotypes as illustrated by results for 6B in this study.

Original languageEnglish
Pages (from-to)401-405
Number of pages5
JournalPediatric Infectious Disease Journal
Volume29
Issue number5
DOIs
Publication statusPublished - May 2010

Keywords

  • Conjugate
  • Correlates of protection
  • Pneumococcal
  • Vaccine

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