TY - JOUR
T1 - Immunity to tetanus and diphtheria in the UK in 2009
AU - Wagner, Karen S.
AU - White, Joanne
AU - Andrews, Nicholas
AU - Borrow, Raymond
AU - Stanford, Elaine
AU - Newton, Emma
AU - Pebody, Richard
PY - 2012/11/19
Y1 - 2012/11/19
N2 - Introduction: This study aimed to estimate the immunity of the UK population to tetanus and diphtheria, including the potential impact of new glycoconjugatate vaccines, and the addition of diphtheria to the school leaver booster in 1994. Methods: Residual sera (n=. 2697) collected in England in 2009/10 were selected from 18 age groups and tested for tetanus and diphtheria antibody. Results were standardised by testing a panel of sera (n=. 150) to enable comparison with a previously (1996) published serosurvey. Data were then standardised to the UK population. Results: In 2009, 83% of the UK population were protected (≥0.1. IU/mL) against tetanus compared to 76% in 1996 (p=. 0.079), and 75% had at least basic protection against diphtheria (≥0.01. IU/mL) in 2009 compared to 60% in 1996 (p<. 0.001). Higher antibody levels were observed in those aged 1-3 years in 2009 compared to 1996 for both tetanus and diphtheria. Higher diphtheria immunity was observed in those aged 16-34 years in 2009 compared to 1996 (geometric mean concentration [GMC] 0.15. IU/mL vs. 0.03. IU/mL, p<. 0.001). Age groups with the largest proportion of susceptible individuals to both tetanus and diphtheria in 2009 were <1 year old (>29% susceptible), 45-69 years (>20% susceptible) and 70+ years (>32% susceptible). Low immunity was observed in those aged 10-11 years (>19% susceptible), between the scheduled preschool and school leaver booster administration. Discussion: The current schedule appears to induce protective levels; increases in the proportions protected/GMCs were observed for the ages receiving vaccinations according to UK policy. Glycoconjugate vaccines appear to have increased immunity, in particular for diphtheria, in preschool age groups. Diphtheria immunity in teenagers and young adults has increased as a result of the addition of diphtheria to the school leaver booster. However, currently older adults remain susceptible, without any further opportunities for immunisations planned according to the present schedule.
AB - Introduction: This study aimed to estimate the immunity of the UK population to tetanus and diphtheria, including the potential impact of new glycoconjugatate vaccines, and the addition of diphtheria to the school leaver booster in 1994. Methods: Residual sera (n=. 2697) collected in England in 2009/10 were selected from 18 age groups and tested for tetanus and diphtheria antibody. Results were standardised by testing a panel of sera (n=. 150) to enable comparison with a previously (1996) published serosurvey. Data were then standardised to the UK population. Results: In 2009, 83% of the UK population were protected (≥0.1. IU/mL) against tetanus compared to 76% in 1996 (p=. 0.079), and 75% had at least basic protection against diphtheria (≥0.01. IU/mL) in 2009 compared to 60% in 1996 (p<. 0.001). Higher antibody levels were observed in those aged 1-3 years in 2009 compared to 1996 for both tetanus and diphtheria. Higher diphtheria immunity was observed in those aged 16-34 years in 2009 compared to 1996 (geometric mean concentration [GMC] 0.15. IU/mL vs. 0.03. IU/mL, p<. 0.001). Age groups with the largest proportion of susceptible individuals to both tetanus and diphtheria in 2009 were <1 year old (>29% susceptible), 45-69 years (>20% susceptible) and 70+ years (>32% susceptible). Low immunity was observed in those aged 10-11 years (>19% susceptible), between the scheduled preschool and school leaver booster administration. Discussion: The current schedule appears to induce protective levels; increases in the proportions protected/GMCs were observed for the ages receiving vaccinations according to UK policy. Glycoconjugate vaccines appear to have increased immunity, in particular for diphtheria, in preschool age groups. Diphtheria immunity in teenagers and young adults has increased as a result of the addition of diphtheria to the school leaver booster. However, currently older adults remain susceptible, without any further opportunities for immunisations planned according to the present schedule.
KW - Diphtheria
KW - Glycoconjugate
KW - Immunity
KW - Seroprevalence
KW - Tetanus
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=84869082139&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2012.09.029
DO - 10.1016/j.vaccine.2012.09.029
M3 - Article
C2 - 23022148
AN - SCOPUS:84869082139
VL - 30
SP - 7111
EP - 7117
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 49
ER -
