TY - JOUR
T1 - Immune response of premature infants to meningococcal serogroup C and combined diphtheria-tetanus toxoids-acellular pertussis-Haemophilus influenzae type b conjugate vaccines
AU - Slack, Martin H.
AU - Schapira, David
AU - Thwaites, Richard J.
AU - Burrage, Moya
AU - Southern, Joanna
AU - Andrews, Nicholas
AU - Borrow, Raymond
AU - Goldblatt, David
AU - Miller, Elizabeth
PY - 2001/12/15
Y1 - 2001/12/15
N2 - To determine the immune response of premature infants to meningococcal serogroup C capsular polysaccharide (MCC) and combined diphtheria-tetanus toxoids-acellular pertussis-Haemophilus influenzae type b (DTaP-Hib) conjugate vaccines, 105 infants born at < 32 weeks' gestation had Hib IgG geometric mean concentrations (GMCs) and MCC serum bactericidal antibody (SBA) geometric mean titers (GMTs) measured 1 month after the third immunization. Term infants served as control subjects. Premature infants had Hib GMCs of 0.27 μg/mL, with 21% achieving GMCs > 1.0 μg/mL, compared with 0.81 μg/mL and 46% in term infants (P < .001 and P = .003, respectively). The MCC SBA GMT was 398, with 99% achieving an SBA ≥8, compared with 380 and 98% in term infants (P = .84 and P = 1.0, respectively). Hib IgG was associated with age at third immunization (P < .001). When combined with the DTaP vaccine used in this study, the Hib GMC of premature infants was extremely low. The SBA GMT to MCC was similar to that of term infants.
AB - To determine the immune response of premature infants to meningococcal serogroup C capsular polysaccharide (MCC) and combined diphtheria-tetanus toxoids-acellular pertussis-Haemophilus influenzae type b (DTaP-Hib) conjugate vaccines, 105 infants born at < 32 weeks' gestation had Hib IgG geometric mean concentrations (GMCs) and MCC serum bactericidal antibody (SBA) geometric mean titers (GMTs) measured 1 month after the third immunization. Term infants served as control subjects. Premature infants had Hib GMCs of 0.27 μg/mL, with 21% achieving GMCs > 1.0 μg/mL, compared with 0.81 μg/mL and 46% in term infants (P < .001 and P = .003, respectively). The MCC SBA GMT was 398, with 99% achieving an SBA ≥8, compared with 380 and 98% in term infants (P = .84 and P = 1.0, respectively). Hib IgG was associated with age at third immunization (P < .001). When combined with the DTaP vaccine used in this study, the Hib GMC of premature infants was extremely low. The SBA GMT to MCC was similar to that of term infants.
UR - http://www.scopus.com/inward/record.url?scp=0035893032&partnerID=8YFLogxK
U2 - 10.1086/324666
DO - 10.1086/324666
M3 - Article
C2 - 11740740
AN - SCOPUS:0035893032
VL - 184
SP - 1617
EP - 1620
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 12
ER -
