Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure

COVIDsortium investigators; COVIDsortium immune correlates network

doi:10.1126/science.abq1841

Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure

COVIDsortium investigators, COVIDsortium immune correlates network

Research output: Contribution to journal › Article › peer-review

221 Citations (Scopus)

Abstract

The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.

Original language	English
Article number	eabq1841
Journal	Science
Volume	377
Issue number	6603
DOIs	https://doi.org/10.1126/science.abq1841
Publication status	Published - 15 Jul 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY)

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10.1126/science.abq1841

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@article{829b75c2a39c4cc987e721ffe2b12d56,

title = "Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure",

abstract = "The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-na{\"i}ve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.",

author = "{COVIDsortium investigators} and {COVIDsortium immune correlates network} and Reynolds, {Catherine J.} and Corinna Pade and Gibbons, {Joseph M.} and Otter, {Ashley D.} and Lin, {Kai Min} and Sandoval, {Diana Mu{\~n}oz} and Pieper, {Franziska P.} and Butler, {David K.} and Siyi Liu and George Joy and Nasim Forooghi and Treibel, {Thomas A.} and Charlotte Manisty and Moon, {James C.} and Amanda Semper and Tim Brooks and {\'A}ine McKnight and Altmann, {Daniel M.} and Boyton, {Rosemary J.} and Hakam Abbass and Aderonke Abiodun and Mashael Alfarih and Zoe Alldis and Amin, {Oliver E.} and Mervyn Andiapen and Jessica Artico and Augusto, {Jo{\~a}o B.} and Baca, {Georgina L.} and Bailey, {Sasha N.L.} and Bhuva, {Anish N.} and Alex Boulter and Ruth Bowles and Bracken, {Olivia V.} and Ben O'Brien and Natalie Bullock and Gabriella Captur and Olivia Carr and Nicola Champion and Carmen Chan and Aneesh Chandran and Tom Coleman and {de Sousa}, {Jorge Couto} and Xose Couto-Parada and Eleanor Cross and Teresa Cutino-Moguel and Silvia D'Arcangelo and Davies, {Rhodri H.} and Jacqueline Hewson and Christopher Moon and Cathy Rowe",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY)",

year = "2022",

month = jul,

day = "15",

doi = "10.1126/science.abq1841",

language = "English",

volume = "377",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6603",

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T1 - Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure

AU - COVIDsortium investigators

AU - COVIDsortium immune correlates network

AU - Reynolds, Catherine J.

AU - Pade, Corinna

AU - Gibbons, Joseph M.

AU - Otter, Ashley D.

AU - Lin, Kai Min

AU - Sandoval, Diana Muñoz

AU - Pieper, Franziska P.

AU - Butler, David K.

AU - Liu, Siyi

AU - Joy, George

AU - Forooghi, Nasim

AU - Treibel, Thomas A.

AU - Manisty, Charlotte

AU - Moon, James C.

AU - Semper, Amanda

AU - Brooks, Tim

AU - McKnight, Áine

AU - Altmann, Daniel M.

AU - Boyton, Rosemary J.

AU - Abbass, Hakam

AU - Abiodun, Aderonke

AU - Alfarih, Mashael

AU - Alldis, Zoe

AU - Amin, Oliver E.

AU - Andiapen, Mervyn

AU - Artico, Jessica

AU - Augusto, João B.

AU - Baca, Georgina L.

AU - Bailey, Sasha N.L.

AU - Bhuva, Anish N.

AU - Boulter, Alex

AU - Bowles, Ruth

AU - Bracken, Olivia V.

AU - O'Brien, Ben

AU - Bullock, Natalie

AU - Captur, Gabriella

AU - Carr, Olivia

AU - Champion, Nicola

AU - Chan, Carmen

AU - Chandran, Aneesh

AU - Coleman, Tom

AU - de Sousa, Jorge Couto

AU - Couto-Parada, Xose

AU - Cross, Eleanor

AU - Cutino-Moguel, Teresa

AU - D'Arcangelo, Silvia

AU - Davies, Rhodri H.

AU - Hewson, Jacqueline

AU - Moon, Christopher

AU - Rowe, Cathy

N1 - Publisher Copyright: © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY)

PY - 2022/7/15

Y1 - 2022/7/15

N2 - The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.

AB - The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.

UR - http://www.scopus.com/inward/record.url?scp=85132254530&partnerID=8YFLogxK

U2 - 10.1126/science.abq1841

DO - 10.1126/science.abq1841

M3 - Article

AN - SCOPUS:85132254530

SN - 0036-8075

VL - 377

JO - Science

JF - Science

IS - 6603

M1 - eabq1841

ER -

Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure

Abstract

Bibliographical note

UN SDGs

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