Identification and screening of carbapenemase-producing Enterobacteriaceae

P. Nordmann; M. Gniadkowski; C. G. Giske; L. Poirel; N. Woodford; V. Miriagou; M. Akova; T. Naas; H. Seifert; D. Livermore; P. Bogaerts; Y. Glupczynski; R. Canton; M. Rossolini G.; A. Adler; Y. Carmeli; S. Navon-Venezia; O. Samuelsen; G. Cornaglia

doi:10.1111/j.1469-0691.2012.03815.x

Identification and screening of carbapenemase-producing Enterobacteriaceae

P. Nordmann^*, M. Gniadkowski, C. G. Giske, L. Poirel, N. Woodford, V. Miriagou, M. Akova, T. Naas, H. Seifert, D. Livermore, P. Bogaerts, Y. Glupczynski, R. Canton, M. Rossolini G., A. Adler, Y. Carmeli, S. Navon-Venezia, O. Samuelsen, G. Cornaglia

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

323 Citations (Scopus)

Abstract

Carbapenem-hydrolysing β-lactamases are the most powerful β-lactamases, being able to hydrolyse almost all β-lactams. They are mostly of the KPC, VIM, IMP, NDM and OXA-48 types. Their current extensive spread worldwide in Enterobacteriaceae is an important source of concern, as these carbapenemase producers are multidrug-resistant. Detection of infected patients and of carriers are the two main approaches for prevention of their spread. Phenotypic and molecular-based techniques are able to identify these carbapenemase producers, although with variable efficiencies. The detection of carriers still relies mostly on the use of screening culture media.

Original language	English
Pages (from-to)	432-438
Number of pages	7
Journal	Clinical Microbiology and Infection
Volume	18
Issue number	5
DOIs	https://doi.org/10.1111/j.1469-0691.2012.03815.x
Publication status	Published - 1 May 2012

Bibliographical note

Funding Information:
This work was partially funded by a grant from INSERM (U914), the European Society for Clinical Microbiology and Infectious Diseases (ESCMID), sponsored the first meeting of the European Network on Carbapenemases held in Paris, September 2011.

Keywords

Antibiotic
Carbapenem
Gram-negatives
Resistance
β-lactams

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1469-0691.2012.03815.x

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Nordmann, P., Gniadkowski, M., Giske, C. G., Poirel, L., Woodford, N., Miriagou, V., Akova, M., Naas, T., Seifert, H., Livermore, D., Bogaerts, P., Glupczynski, Y., Canton, R., Rossolini G., M., Adler, A., Carmeli, Y., Navon-Venezia, S., Samuelsen, O., & Cornaglia, G. (2012). Identification and screening of carbapenemase-producing Enterobacteriaceae. Clinical Microbiology and Infection, 18(5), 432-438. https://doi.org/10.1111/j.1469-0691.2012.03815.x

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abstract = "Carbapenem-hydrolysing β-lactamases are the most powerful β-lactamases, being able to hydrolyse almost all β-lactams. They are mostly of the KPC, VIM, IMP, NDM and OXA-48 types. Their current extensive spread worldwide in Enterobacteriaceae is an important source of concern, as these carbapenemase producers are multidrug-resistant. Detection of infected patients and of carriers are the two main approaches for prevention of their spread. Phenotypic and molecular-based techniques are able to identify these carbapenemase producers, although with variable efficiencies. The detection of carriers still relies mostly on the use of screening culture media.",

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Nordmann, P, Gniadkowski, M, Giske, CG, Poirel, L, Woodford, N, Miriagou, V, Akova, M, Naas, T, Seifert, H, Livermore, D, Bogaerts, P, Glupczynski, Y, Canton, R, Rossolini G., M, Adler, A, Carmeli, Y, Navon-Venezia, S, Samuelsen, O & Cornaglia, G 2012, 'Identification and screening of carbapenemase-producing Enterobacteriaceae', Clinical Microbiology and Infection, vol. 18, no. 5, pp. 432-438. https://doi.org/10.1111/j.1469-0691.2012.03815.x

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AU - Nordmann, P.

AU - Gniadkowski, M.

AU - Giske, C. G.

AU - Poirel, L.

AU - Woodford, N.

AU - Miriagou, V.

AU - Akova, M.

AU - Naas, T.

AU - Seifert, H.

AU - Livermore, D.

AU - Bogaerts, P.

AU - Glupczynski, Y.

AU - Canton, R.

AU - Rossolini G., M.

AU - Adler, A.

AU - Carmeli, Y.

AU - Navon-Venezia, S.

AU - Samuelsen, O.

AU - Cornaglia, G.

N1 - Funding Information: This work was partially funded by a grant from INSERM (U914), the European Society for Clinical Microbiology and Infectious Diseases (ESCMID), sponsored the first meeting of the European Network on Carbapenemases held in Paris, September 2011.

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AB - Carbapenem-hydrolysing β-lactamases are the most powerful β-lactamases, being able to hydrolyse almost all β-lactams. They are mostly of the KPC, VIM, IMP, NDM and OXA-48 types. Their current extensive spread worldwide in Enterobacteriaceae is an important source of concern, as these carbapenemase producers are multidrug-resistant. Detection of infected patients and of carriers are the two main approaches for prevention of their spread. Phenotypic and molecular-based techniques are able to identify these carbapenemase producers, although with variable efficiencies. The detection of carriers still relies mostly on the use of screening culture media.

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KW - Gram-negatives

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KW - β-lactams

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ER -

Identification and screening of carbapenemase-producing Enterobacteriaceae

Abstract

Bibliographical note

Keywords

UN SDGs

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