HTLV-III SEROLOGY DISTINGUISHES ATYPICAL AND ENDEMIC KAPOSI'S SARCOMA IN AFRICA

A. C. Bayley*, R. Cheingsong-Popov, A. G. Dalgleish, R. G. Downing, Richard Tedder, R. A. Weiss

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)

Abstract

Serum samples from African patients with Kaposi's sarcoma and acquired-immunodeficiency-syndrome-related (AIDS-related) disorders and from normal subjects in Uganda and Zambia were tested for antibodies to the human T-lymphotropic retroviruses (HTLV) types I, II, and III. Nearly 90% of patients with AIDS-related disorders or with atypical, aggressive Kaposi's sarcoma were seropositive for HTLV-III in both countries, whereas only 17% of patients with classic endemic Kaposi's sarcoma were seropositive. Among the controls 20% were seropositive for HTLV-III in Uganda but only 2% in Zambia. None of the subjects tested had antibodies to HTLV-I or HTLV-II. These results are further evidence of the emergence of a clinically atypical form of Kaposi's sarcoma in Africans, which resembles that seen in American patients with AIDS, and which is associated with HTLV-III infection. The low frequency of antibodies to HTLV-III in the normal Zambian population together with the first appearance of HTLV-III-associated diseases during the past 2 years suggests that this virus is new to Zambia, although it may have been present in Uganda for longer.

Original languageEnglish
Pages (from-to)359-361
Number of pages3
JournalThe Lancet
Volume325
Issue number8425
DOIs
Publication statusPublished - 16 Feb 1985

Bibliographical note

Funding Information:
samples and clinical notes, and Anne Smith and Paul Clapham, for technical help. This study was supported by the Medical Research Council and the Cancer Research Campaign.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

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