Hospital disinfectants and spore formation by Clostridium difficile

Mark H. Wilcox; Warren N. Fawley

doi:10.1016/S0140-6736(00)02819-1

Hospital disinfectants and spore formation by Clostridium difficile

Mark H. Wilcox^*
, Warren N. Fawley

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

142 Citations (Scopus)

Abstract

Evidence is lacking on how best to decontaminate the hospital environment of Clostridium difficile. We compared sporulation levels in the UK epidemic C difficile strain (P24), another clinical isolate (B31), and an environmental strain (E4) cultured in faecal emulsion containing subinhibitory concentrations of one of five hospital cleaning agents. The epidemic strain produced significantly more spores than the non-prevalent strains, and sporulation was further enhanced when this strain was cultured in faeces exposed to non-chlorine-based cleaning agents. The choice of cleaning agent can have a substantial effect on the persistence of C difficile spores in the hospital environment.

Original language	English
Pages (from-to)	1324
Number of pages	1
Journal	The Lancet
Volume	356
Issue number	9238
DOIs	https://doi.org/10.1016/S0140-6736(00)02819-1
Publication status	Published - 14 Oct 2000
Externally published	Yes

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10.1016/S0140-6736(00)02819-1

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title = "Hospital disinfectants and spore formation by Clostridium difficile",

abstract = "Evidence is lacking on how best to decontaminate the hospital environment of Clostridium difficile. We compared sporulation levels in the UK epidemic C difficile strain (P24), another clinical isolate (B31), and an environmental strain (E4) cultured in faecal emulsion containing subinhibitory concentrations of one of five hospital cleaning agents. The epidemic strain produced significantly more spores than the non-prevalent strains, and sporulation was further enhanced when this strain was cultured in faeces exposed to non-chlorine-based cleaning agents. The choice of cleaning agent can have a substantial effect on the persistence of C difficile spores in the hospital environment.",

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AU - Fawley, Warren N.

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AB - Evidence is lacking on how best to decontaminate the hospital environment of Clostridium difficile. We compared sporulation levels in the UK epidemic C difficile strain (P24), another clinical isolate (B31), and an environmental strain (E4) cultured in faecal emulsion containing subinhibitory concentrations of one of five hospital cleaning agents. The epidemic strain produced significantly more spores than the non-prevalent strains, and sporulation was further enhanced when this strain was cultured in faeces exposed to non-chlorine-based cleaning agents. The choice of cleaning agent can have a substantial effect on the persistence of C difficile spores in the hospital environment.

UR - https://www.scopus.com/pages/publications/0034649081

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DO - 10.1016/S0140-6736(00)02819-1

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JO - The Lancet

JF - The Lancet

IS - 9238

ER -

Hospital disinfectants and spore formation by Clostridium difficile

Abstract

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