HIV seroconversions among male non-occupational post-exposure prophylaxis service users: A data linkage study

Anna B. Pierce, Keflemariam Yohannes, Rebecca Guy, Kerrie M. Watson, Jude Armishaw, Brian Price, Jennifer F. Hoy, Edwina J. Wright, Mark A. Stoov́

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background: Despite widespread prescription of non-occupational post-exposure prophylaxis (NPEP) in Victoria, little is known about subsequent HIV acquisition among NPEP users. We linked the Victorian NPEP Service (VNPEPS) database and the Victorian HIV Surveillance Registry to determine the number, incidence rate and predictive factors of HIV seroconversions among users of the VNPEPS. Methods: Records from male patients that received NPEP in the VNPEPS database (n=1420) between January 2001 and February 2008 were linked with all entries in the Victorian HIV Surveillance Registry up to May 2008. Results: Sixty-one men who presented to the VNPEPS were identified as HIV seropositive; 16 of these were diagnosed at initial presentation for NPEP. The incidence of HIV seroconversion in males who were HIV seronegative at first presentation for NPEP was 1.27 (95% confidence interval 0.951.70) per 100 person-years. There was no association between HIV seroconversion and number of NPEP presentations or age. The median age of seroconversion was 34.6 years. Conclusion: The incidence of HIV infection among men presenting to the VNPEPS is slightly lower than the HIV incidence in NPEP users in a recent Australian cohort study of men who have sex with men, but higher than HIV incidence in general gay male populations. Frequency of NPEP use was not associated with risk of HIV seroconversion. Examination of risk behaviour before and after NPEP use in this population is required to further assess the impact of NPEP availability and use on HIV incidence rates and risk behaviour in Australia.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalSexual Health
Issue number2
Publication statusPublished - 2011
Externally publishedYes


  • AIDS
  • Australia
  • HIV incidence
  • HIV prevention.


Dive into the research topics of 'HIV seroconversions among male non-occupational post-exposure prophylaxis service users: A data linkage study'. Together they form a unique fingerprint.

Cite this