Histopathological findings from the investigation of paediatric acute hepatitis of unknown aetiology, United Kingdom 2022

Helen Callaby; Emma McGuire; Sanjay Rajwal; Jens Stahlschmidt; Jane Hartley; Rachel M. Brown; Maesha Deheragoda; Alberto Quaglia; Tommy Rampling; Catherine F. Houlihan; N. Claire Gordon; Colin S. Brown; Ruth Simmons; Anda Samson; Sema Mandal; Tassos Grammatikopoulos; Alicia Demirjian

doi:10.1002/jpn3.12133

Histopathological findings from the investigation of paediatric acute hepatitis of unknown aetiology, United Kingdom 2022

Helen Callaby^*, Emma McGuire, Sanjay Rajwal, Jens Stahlschmidt, Jane Hartley, Rachel M. Brown, Maesha Deheragoda, Alberto Quaglia, Tommy Rampling, Catherine F. Houlihan, N. Claire Gordon, Colin S. Brown, Ruth Simmons, Anda Samson, Sema Mandal, Tassos Grammatikopoulos, Alicia Demirjian

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

In 2022, there were global reports of increased numbers of acute hepatitis not explained by hepatitis A–E virus infection in children. This manuscript summarises histopathology results from 20 patients in the United Kingdom who underwent liver transplant or had a liver biopsy as part of aetiological investigations. All available histopathological samples were reviewed centrally as part of the outbreak investigation. A working group comprised of infection specialists, hepatologists and histopathologists met virtually to review the cases, presentation, investigations and histopathology. All 20 liver samples had evidence of inflammation without significant interface activity, and submassive confluent pan-lobular or multilobular hepatocellular necrosis. Overall, the predominant histopathological findings were of acute nonspecific hepatitis with submassive hepatic necrosis and central vein perivenulitis and endothelitis. Histopathological findings were a poor indicator of aetiology.

Original language	English
Pages (from-to)	534-538
Number of pages	5
Journal	Journal of Pediatric Gastroenterology and Nutrition
Volume	78
Issue number	3
DOIs	https://doi.org/10.1002/jpn3.12133
Publication status	Published - Mar 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

Keywords

hepatitis
histopathology
liver failure
paediatric
transplant

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jpn3.12133

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Callaby, H., McGuire, E., Rajwal, S., Stahlschmidt, J., Hartley, J., Brown, R. M., Deheragoda, M., Quaglia, A., Rampling, T., Houlihan, C. F., Claire Gordon, N., Brown, C. S., Simmons, R., Samson, A., Mandal, S., Grammatikopoulos, T., & Demirjian, A. (2024). Histopathological findings from the investigation of paediatric acute hepatitis of unknown aetiology, United Kingdom 2022. Journal of Pediatric Gastroenterology and Nutrition, 78(3), 534-538. https://doi.org/10.1002/jpn3.12133

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abstract = "In 2022, there were global reports of increased numbers of acute hepatitis not explained by hepatitis A–E virus infection in children. This manuscript summarises histopathology results from 20 patients in the United Kingdom who underwent liver transplant or had a liver biopsy as part of aetiological investigations. All available histopathological samples were reviewed centrally as part of the outbreak investigation. A working group comprised of infection specialists, hepatologists and histopathologists met virtually to review the cases, presentation, investigations and histopathology. All 20 liver samples had evidence of inflammation without significant interface activity, and submassive confluent pan-lobular or multilobular hepatocellular necrosis. Overall, the predominant histopathological findings were of acute nonspecific hepatitis with submassive hepatic necrosis and central vein perivenulitis and endothelitis. Histopathological findings were a poor indicator of aetiology.",

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author = "Helen Callaby and Emma McGuire and Sanjay Rajwal and Jens Stahlschmidt and Jane Hartley and Brown, {Rachel M.} and Maesha Deheragoda and Alberto Quaglia and Tommy Rampling and Houlihan, {Catherine F.} and {Claire Gordon}, N. and Brown, {Colin S.} and Ruth Simmons and Anda Samson and Sema Mandal and Tassos Grammatikopoulos and Alicia Demirjian",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.",

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Callaby, H, McGuire, E, Rajwal, S, Stahlschmidt, J, Hartley, J, Brown, RM, Deheragoda, M, Quaglia, A, Rampling, T, Houlihan, CF, Claire Gordon, N, Brown, CS , Simmons, R, Samson, A, Mandal, S, Grammatikopoulos, T & Demirjian, A 2024, 'Histopathological findings from the investigation of paediatric acute hepatitis of unknown aetiology, United Kingdom 2022', Journal of Pediatric Gastroenterology and Nutrition, vol. 78, no. 3, pp. 534-538. https://doi.org/10.1002/jpn3.12133

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AU - Callaby, Helen

AU - McGuire, Emma

AU - Rajwal, Sanjay

AU - Stahlschmidt, Jens

AU - Hartley, Jane

AU - Brown, Rachel M.

AU - Deheragoda, Maesha

AU - Quaglia, Alberto

AU - Rampling, Tommy

AU - Houlihan, Catherine F.

AU - Claire Gordon, N.

AU - Brown, Colin S.

AU - Simmons, Ruth

AU - Samson, Anda

AU - Mandal, Sema

AU - Grammatikopoulos, Tassos

AU - Demirjian, Alicia

N1 - Publisher Copyright: © 2024 The Authors. Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

PY - 2024/3

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AB - In 2022, there were global reports of increased numbers of acute hepatitis not explained by hepatitis A–E virus infection in children. This manuscript summarises histopathology results from 20 patients in the United Kingdom who underwent liver transplant or had a liver biopsy as part of aetiological investigations. All available histopathological samples were reviewed centrally as part of the outbreak investigation. A working group comprised of infection specialists, hepatologists and histopathologists met virtually to review the cases, presentation, investigations and histopathology. All 20 liver samples had evidence of inflammation without significant interface activity, and submassive confluent pan-lobular or multilobular hepatocellular necrosis. Overall, the predominant histopathological findings were of acute nonspecific hepatitis with submassive hepatic necrosis and central vein perivenulitis and endothelitis. Histopathological findings were a poor indicator of aetiology.

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ER -

Histopathological findings from the investigation of paediatric acute hepatitis of unknown aetiology, United Kingdom 2022

Abstract

Bibliographical note

Keywords

UN SDGs

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