TY - JOUR
T1 - Highlights of the 14th International Bordetella Symposium
AU - Navarrete, Kevin Munoz
AU - Edwards, Kathryn M.
AU - Mills, Kingston H.G.
AU - Kamanová, Jana
AU - Rodriguez, María Eugenia
AU - Gorringe, Andrew
AU - Preston, Andrew
AU - Kampmann, Beate
AU - Gestal, Monica C.
AU - Harvill, Eric T.
AU - Dubey, Purnima
AU - Diavatopoulos, Dimitri A.
AU - Mattoo, Seema
AU - Scanlon, Karen M.
AU - Locht, Camille
AU - Sebo, Peter
N1 - Publisher Copyright:
Copyright © 2025 Munoz Navarrete et al.
PY - 2025/6
Y1 - 2025/6
N2 - Pertussis, or whooping cough, is a highly contagious and acute respiratory illness caused primarily by the gram-negative coccobacillus Bordetella pertussis. Despite near-universal vaccination, pertussis remains one of the least-controlled vaccine-preventable infectious diseases. Since 2023, pertussis incidence has been rising, and widespread pertussis outbreaks have resurged in many countries. In response to these emerging challenges, almost 300 experts from institutions across 24 countries convened at the 14th International Bordetella Symposium in Prague, Czech Republic, from 24 to 28 June 2024 to discuss pertussis epidemiology and research and strategies to mitigate the global pertussis burden. We present here the highlights of the symposium, comprising epidemiological and clinical aspects of Bordetella infections, results of clinical trials of pertussis vaccination in pregnant women and effectiveness of maternal vaccination in protecting newborn infants in Africa and Europe, the controlled human infection model (CHIM), and the latest insights into the biology, immunology, and pathogenesis of B. pertussis infection.
AB - Pertussis, or whooping cough, is a highly contagious and acute respiratory illness caused primarily by the gram-negative coccobacillus Bordetella pertussis. Despite near-universal vaccination, pertussis remains one of the least-controlled vaccine-preventable infectious diseases. Since 2023, pertussis incidence has been rising, and widespread pertussis outbreaks have resurged in many countries. In response to these emerging challenges, almost 300 experts from institutions across 24 countries convened at the 14th International Bordetella Symposium in Prague, Czech Republic, from 24 to 28 June 2024 to discuss pertussis epidemiology and research and strategies to mitigate the global pertussis burden. We present here the highlights of the symposium, comprising epidemiological and clinical aspects of Bordetella infections, results of clinical trials of pertussis vaccination in pregnant women and effectiveness of maternal vaccination in protecting newborn infants in Africa and Europe, the controlled human infection model (CHIM), and the latest insights into the biology, immunology, and pathogenesis of B. pertussis infection.
KW - Bordetella pertussis
KW - epidemiology
KW - pathogenesis
KW - toxins
KW - vaccines
KW - virulence
UR - https://www.scopus.com/pages/publications/105010247524
U2 - 10.1128/msphere.00189-25
DO - 10.1128/msphere.00189-25
M3 - Article
C2 - 40377335
AN - SCOPUS:105010247524
SN - 2379-5042
VL - 10
JO - mSphere
JF - mSphere
IS - 6
ER -
