High percentage of recent HIV infection leading to onward transmission in Odessa, Ukraine associated with young adults

Ruth Simmons; Igor Semenenko; Maria Tolpina; Rostislav Tereschenko; Ludmila Kotlik; Lyubov Zasyptka; Gary Murphy; Elaine McKinney; Andrew Copas; Ruslan Malyuta; Kholoud Porter

doi:10.1007/s10461-013-0518-9

High percentage of recent HIV infection leading to onward transmission in Odessa, Ukraine associated with young adults

Ruth Simmons^*, Igor Semenenko, Maria Tolpina, Rostislav Tereschenko, Ludmila Kotlik, Lyubov Zasyptka, Gary Murphy, Elaine McKinney, Andrew Copas, Ruslan Malyuta, Kholoud Porter

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The proportion of new HIV diagnoses between May and December 2009 across Odessa recently-infected was estimated using the BED-CEIA assay. Logistic regression models were used to explore factors associated with testing as recent. Of 1,313 newly-diagnosed individuals, 321 (24 %) were classified as recent. Recent infection was less likely among older adults [odds ratio (OR) = 0.70 per 10-year increase, 95 % CI 0.60-0.82]. Compared to men residing in Odessa city, women in rural Odessa and non-resident men were more likely to be recently-infected (OR 1.85, 1.26-2.71 and 2.83, 1.15-6.97, respectively). Reason for test was not associated with recent infection. In sensitivity analysis, after excluding individuals tested due to clinical indications, the proportion recently-infected and the association with age remained virtually unchanged. Our findings suggest a high risk of onward transmission, particularly in younger age groups. These findings highlight the need for tailored prevention strategies and ongoing RITA testing to monitor and evaluate effectiveness of prevention programmes.

Original language	English
Pages (from-to)	411-418
Number of pages	8
Journal	AIDS and Behavior
Volume	18
Issue number	2
DOIs	https://doi.org/10.1007/s10461-013-0518-9
Publication status	Published - Feb 2014

Bibliographical note

Funding Information:
This study was conducted on behalf of CASCADE Collaboration in EuroCoord. The members of CASCADE Collaboration in EuroCoord are given in Appendix. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under EuroCoord grant agreement n° 260694. Ruth Simmons is funded through a doctoral grant from the Medical Research Council, UK.

Funding Information:
The study was part of CASCADE within EuroCoord (www.EuroCoord.net) funded by the European Union Framework Programme VII. Ethics approval was given by the Odessa Province Sanitarium and Epidemiological Station including that additional consent is not required from participants.

Keywords

BED-CEIA
HIV incidence
Onward transmission
RITA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10461-013-0518-9

Cite this

Simmons, Ruth ; Semenenko, Igor ; Tolpina, Maria ; Tereschenko, Rostislav ; Kotlik, Ludmila ; Zasyptka, Lyubov ; Murphy, Gary ; McKinney, Elaine ; Copas, Andrew ; Malyuta, Ruslan ; Porter, Kholoud. / High percentage of recent HIV infection leading to onward transmission in Odessa, Ukraine associated with young adults. In: AIDS and Behavior. 2014 ; Vol. 18, No. 2. pp. 411-418.

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title = "High percentage of recent HIV infection leading to onward transmission in Odessa, Ukraine associated with young adults",

abstract = "The proportion of new HIV diagnoses between May and December 2009 across Odessa recently-infected was estimated using the BED-CEIA assay. Logistic regression models were used to explore factors associated with testing as recent. Of 1,313 newly-diagnosed individuals, 321 (24 %) were classified as recent. Recent infection was less likely among older adults [odds ratio (OR) = 0.70 per 10-year increase, 95 % CI 0.60-0.82]. Compared to men residing in Odessa city, women in rural Odessa and non-resident men were more likely to be recently-infected (OR 1.85, 1.26-2.71 and 2.83, 1.15-6.97, respectively). Reason for test was not associated with recent infection. In sensitivity analysis, after excluding individuals tested due to clinical indications, the proportion recently-infected and the association with age remained virtually unchanged. Our findings suggest a high risk of onward transmission, particularly in younger age groups. These findings highlight the need for tailored prevention strategies and ongoing RITA testing to monitor and evaluate effectiveness of prevention programmes.",

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note = "Funding Information: This study was conducted on behalf of CASCADE Collaboration in EuroCoord. The members of CASCADE Collaboration in EuroCoord are given in Appendix. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under EuroCoord grant agreement n° 260694. Ruth Simmons is funded through a doctoral grant from the Medical Research Council, UK. Funding Information: The study was part of CASCADE within EuroCoord (www.EuroCoord.net) funded by the European Union Framework Programme VII. Ethics approval was given by the Odessa Province Sanitarium and Epidemiological Station including that additional consent is not required from participants.",

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High percentage of recent HIV infection leading to onward transmission in Odessa, Ukraine associated with young adults. / Simmons, Ruth; Semenenko, Igor; Tolpina, Maria; Tereschenko, Rostislav; Kotlik, Ludmila; Zasyptka, Lyubov; Murphy, Gary; McKinney, Elaine; Copas, Andrew; Malyuta, Ruslan; Porter, Kholoud.

In: AIDS and Behavior, Vol. 18, No. 2, 02.2014, p. 411-418.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - High percentage of recent HIV infection leading to onward transmission in Odessa, Ukraine associated with young adults

AU - Simmons, Ruth

AU - Semenenko, Igor

AU - Tolpina, Maria

AU - Tereschenko, Rostislav

AU - Kotlik, Ludmila

AU - Zasyptka, Lyubov

AU - Murphy, Gary

AU - McKinney, Elaine

AU - Copas, Andrew

AU - Malyuta, Ruslan

AU - Porter, Kholoud

N1 - Funding Information: This study was conducted on behalf of CASCADE Collaboration in EuroCoord. The members of CASCADE Collaboration in EuroCoord are given in Appendix. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under EuroCoord grant agreement n° 260694. Ruth Simmons is funded through a doctoral grant from the Medical Research Council, UK. Funding Information: The study was part of CASCADE within EuroCoord (www.EuroCoord.net) funded by the European Union Framework Programme VII. Ethics approval was given by the Odessa Province Sanitarium and Epidemiological Station including that additional consent is not required from participants.

PY - 2014/2

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N2 - The proportion of new HIV diagnoses between May and December 2009 across Odessa recently-infected was estimated using the BED-CEIA assay. Logistic regression models were used to explore factors associated with testing as recent. Of 1,313 newly-diagnosed individuals, 321 (24 %) were classified as recent. Recent infection was less likely among older adults [odds ratio (OR) = 0.70 per 10-year increase, 95 % CI 0.60-0.82]. Compared to men residing in Odessa city, women in rural Odessa and non-resident men were more likely to be recently-infected (OR 1.85, 1.26-2.71 and 2.83, 1.15-6.97, respectively). Reason for test was not associated with recent infection. In sensitivity analysis, after excluding individuals tested due to clinical indications, the proportion recently-infected and the association with age remained virtually unchanged. Our findings suggest a high risk of onward transmission, particularly in younger age groups. These findings highlight the need for tailored prevention strategies and ongoing RITA testing to monitor and evaluate effectiveness of prevention programmes.

AB - The proportion of new HIV diagnoses between May and December 2009 across Odessa recently-infected was estimated using the BED-CEIA assay. Logistic regression models were used to explore factors associated with testing as recent. Of 1,313 newly-diagnosed individuals, 321 (24 %) were classified as recent. Recent infection was less likely among older adults [odds ratio (OR) = 0.70 per 10-year increase, 95 % CI 0.60-0.82]. Compared to men residing in Odessa city, women in rural Odessa and non-resident men were more likely to be recently-infected (OR 1.85, 1.26-2.71 and 2.83, 1.15-6.97, respectively). Reason for test was not associated with recent infection. In sensitivity analysis, after excluding individuals tested due to clinical indications, the proportion recently-infected and the association with age remained virtually unchanged. Our findings suggest a high risk of onward transmission, particularly in younger age groups. These findings highlight the need for tailored prevention strategies and ongoing RITA testing to monitor and evaluate effectiveness of prevention programmes.

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KW - HIV incidence

KW - Onward transmission

KW - RITA

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M3 - Article

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AN - SCOPUS:84893857650

VL - 18

SP - 411

EP - 418

JO - AIDS and Behavior

JF - AIDS and Behavior

SN - 1090-7165

IS - 2

ER -

High percentage of recent HIV infection leading to onward transmission in Odessa, Ukraine associated with young adults

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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Cite this