High-level aminoglycoside-resistant enterococcal endocarditis: A therapeutic challenge

Alison Muir; Das G. Pillay; Robert Hill

doi:10.1097/IPC.0b013e31825aee03

High-level aminoglycoside-resistant enterococcal endocarditis: A therapeutic challenge

Alison Muir^*, Das G. Pillay, Robert Hill

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Enterococci with high-level resistance to multiple aminoglycosides account for approximately one quarter of enterococcal endocarditis cases, yet there is a lack of consensus concerning optimal therapy. This issue is particularly topical as new British guidelines for the treatment of endocarditis have recently been published. We present a case of endocarditis caused by enterococci with high-level aminoglycoside resistance that was successfully treated with the counter-intuitive combination of amoxicillin and ceftriaxone. The rationale and evidence for this decision is reviewed, and other possible treatments are discussed.

Original language	English
Pages (from-to)	3-5
Number of pages	3
Journal	Infectious Diseases in Clinical Practice
Volume	21
Issue number	1
DOIs	https://doi.org/10.1097/IPC.0b013e31825aee03
Publication status	Published - Jan 2013

Keywords

Enterococcus faecalis
ceftriaxone
endocarditis
synergy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/IPC.0b013e31825aee03

Cite this

@article{c6428bb08c0642c386c2516f744ee5d4,

title = "High-level aminoglycoside-resistant enterococcal endocarditis: A therapeutic challenge",

abstract = "Enterococci with high-level resistance to multiple aminoglycosides account for approximately one quarter of enterococcal endocarditis cases, yet there is a lack of consensus concerning optimal therapy. This issue is particularly topical as new British guidelines for the treatment of endocarditis have recently been published. We present a case of endocarditis caused by enterococci with high-level aminoglycoside resistance that was successfully treated with the counter-intuitive combination of amoxicillin and ceftriaxone. The rationale and evidence for this decision is reviewed, and other possible treatments are discussed.",

keywords = "Enterococcus faecalis, ceftriaxone, endocarditis, synergy",

author = "Alison Muir and Pillay, {Das G.} and Robert Hill",

year = "2013",

month = jan,

doi = "10.1097/IPC.0b013e31825aee03",

language = "English",

volume = "21",

pages = "3--5",

journal = "Infectious Diseases in Clinical Practice",

issn = "1056-9103",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "1",

}

TY - JOUR

T1 - High-level aminoglycoside-resistant enterococcal endocarditis

T2 - A therapeutic challenge

AU - Muir, Alison

AU - Pillay, Das G.

AU - Hill, Robert

PY - 2013/1

Y1 - 2013/1

N2 - Enterococci with high-level resistance to multiple aminoglycosides account for approximately one quarter of enterococcal endocarditis cases, yet there is a lack of consensus concerning optimal therapy. This issue is particularly topical as new British guidelines for the treatment of endocarditis have recently been published. We present a case of endocarditis caused by enterococci with high-level aminoglycoside resistance that was successfully treated with the counter-intuitive combination of amoxicillin and ceftriaxone. The rationale and evidence for this decision is reviewed, and other possible treatments are discussed.

AB - Enterococci with high-level resistance to multiple aminoglycosides account for approximately one quarter of enterococcal endocarditis cases, yet there is a lack of consensus concerning optimal therapy. This issue is particularly topical as new British guidelines for the treatment of endocarditis have recently been published. We present a case of endocarditis caused by enterococci with high-level aminoglycoside resistance that was successfully treated with the counter-intuitive combination of amoxicillin and ceftriaxone. The rationale and evidence for this decision is reviewed, and other possible treatments are discussed.

KW - Enterococcus faecalis

KW - ceftriaxone

KW - endocarditis

KW - synergy

UR - http://www.scopus.com/inward/record.url?scp=84872081339&partnerID=8YFLogxK

U2 - 10.1097/IPC.0b013e31825aee03

DO - 10.1097/IPC.0b013e31825aee03

M3 - Review article

AN - SCOPUS:84872081339

SN - 1056-9103

VL - 21

SP - 3

EP - 5

JO - Infectious Diseases in Clinical Practice

JF - Infectious Diseases in Clinical Practice

IS - 1

ER -

High-level aminoglycoside-resistant enterococcal endocarditis: A therapeutic challenge

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this