TY - JOUR
T1 - Hepatitis e autochthonous infection in chronic liver disease
AU - Lockwood, Gabrielle L.
AU - Fernandez-Barredo, Salceda
AU - Bendall, Richard
AU - Banks, Malcolm
AU - Ijaz, Samreen
AU - Dalton, Harry R.
PY - 2008/8
Y1 - 2008/8
N2 - Hepatitis E virus is endemic in many parts of the developing world and causes a self-limiting hepatitis in young adults, except in pregnant women and patients with chronic liver disease, where the mortality is high. Locally acquired hepatitis E is increasingly recognized in the developed world. It is caused by hepatitis E virus genotype 3, affects the middle-aged and the elderly, and may be a zoonotic infection from pigs. We present a case of locally acquired hepatitis E infection in a patient with previously undiagnosed cirrhosis, which resulted in subacute liver failure and death. We describe our attempt to trace this infection to a free-range pig farm adjacent to the patients place of employment. Hepatitis E infection should be considered in the differential diagnosis in patients with decompensated chronic liver disease whatever their age or travel history. When found, the prognosis may be poor.
AB - Hepatitis E virus is endemic in many parts of the developing world and causes a self-limiting hepatitis in young adults, except in pregnant women and patients with chronic liver disease, where the mortality is high. Locally acquired hepatitis E is increasingly recognized in the developed world. It is caused by hepatitis E virus genotype 3, affects the middle-aged and the elderly, and may be a zoonotic infection from pigs. We present a case of locally acquired hepatitis E infection in a patient with previously undiagnosed cirrhosis, which resulted in subacute liver failure and death. We describe our attempt to trace this infection to a free-range pig farm adjacent to the patients place of employment. Hepatitis E infection should be considered in the differential diagnosis in patients with decompensated chronic liver disease whatever their age or travel history. When found, the prognosis may be poor.
KW - Autochthonous
KW - Chronic liver disease
KW - Hepatitis E
KW - Superinfection
KW - Zoonosis
UR - http://www.scopus.com/inward/record.url?scp=52149092098&partnerID=8YFLogxK
U2 - 10.1097/MEG.0b013e3282f1cbff
DO - 10.1097/MEG.0b013e3282f1cbff
M3 - Article
C2 - 18617787
AN - SCOPUS:52149092098
VL - 20
SP - 800
EP - 803
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
SN - 0954-691X
IS - 8
ER -