Hepatitis e autochthonous infection in chronic liver disease

Gabrielle L. Lockwood, Salceda Fernandez-Barredo, Richard Bendall, Malcolm Banks, Samreen Ijaz, Harry R. Dalton

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    29 Citations (Scopus)


    Hepatitis E virus is endemic in many parts of the developing world and causes a self-limiting hepatitis in young adults, except in pregnant women and patients with chronic liver disease, where the mortality is high. Locally acquired hepatitis E is increasingly recognized in the developed world. It is caused by hepatitis E virus genotype 3, affects the middle-aged and the elderly, and may be a zoonotic infection from pigs. We present a case of locally acquired hepatitis E infection in a patient with previously undiagnosed cirrhosis, which resulted in subacute liver failure and death. We describe our attempt to trace this infection to a free-range pig farm adjacent to the patients place of employment. Hepatitis E infection should be considered in the differential diagnosis in patients with decompensated chronic liver disease whatever their age or travel history. When found, the prognosis may be poor.

    Original languageEnglish
    Pages (from-to)800-803
    Number of pages4
    JournalEuropean Journal of Gastroenterology and Hepatology
    Issue number8
    Publication statusPublished - Aug 2008


    • Autochthonous
    • Chronic liver disease
    • Hepatitis E
    • Superinfection
    • Zoonosis


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